CDK2, cyclin dependent kinase 2, 1017

N. diseases: 270; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017638
Disease: Glioma
Glioma
0.100 AlteredExpression disease BEFREE Knockdown of HDAC4 substantially promoted the expression of CDK1 and CDK2 and vimentin in glioma U251 cells. 30272277 2018
CUI: C0017638
Disease: Glioma
Glioma
0.100 AlteredExpression disease BEFREE Additionally, the mechanism of HOTTIP-mediated reduction of glioma cell growth may involve the suppression of cyclin A and CDK2 protein expression, which increases P53 protein expression via the down-regulation of BRE. 27733185 2016
CUI: C0017638
Disease: Glioma
Glioma
0.100 GeneticVariation disease BEFREE These findings show that CDKN2 p16 540 C>G, CDKN2 p16 580 C>T and MDM2 SNP309 T>G variants and their haplotypes may be risk factors for the development of primary brain tumors, especially of glioma. 26124340 2015
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE CCRK expression was knocked down in human glioma U-373 MG and U-87 MG cells with small-interfering RNAs and short hairpin RNAs (siCCRK and shCCRK, respectively), and cell proliferation, cell cycle distribution, and cyclin-dependent kinase 2 (CDK2) phosphorylation were examined. 17565152 2007
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE Molecular analysis of CDKN2 (p16) in gliomas associated with clinical data. 11496313 2001
CUI: C0017638
Disease: Glioma
Glioma
0.100 GeneticVariation disease BEFREE The occurrence of p16/CDKN2 germline mutations in 12 Icelandic melanoma kindreds (kindreds with two or more cases of melanoma or melanoma, pancreas and/or glioma cases) was examined. 10651484 1998
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE Adenovirus-mediated p16/CDKN2 gene transfer suppresses glioma invasion in vitro. 9366522 1997
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE We have analysed the significance of the loss of this gene in gliomas by introducing the cDNA for p16INK4A into the human glioma cell line U-1242 MG which has a deleted CDKN2 locus. 9247304 1997
CUI: C0017638
Disease: Glioma
Glioma
0.100 AlteredExpression disease BEFREE These results suggest that p16/CDKN2 inactivation is a significant factor in the genesis and progression of gliomas and that the restoration of the wild-type p16 protein could have clinical and therapeutic utility. 8552379 1996
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE The findings also provide corroborative evidence that CDKN2/p16 and RB are the critical glioma tumor suppressor genes on chromosomes 9p and 13q, respectively. 8548755 1996
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE Detection of CDKN2 deletions in tumor cell lines and primary glioma by interphase fluorescence in situ hybridization. 7867008 1995
CUI: C0017638
Disease: Glioma
Glioma
0.100 AlteredExpression disease BEFREE These results suggest: (a) the involvement of P16INK4 in glioma progression; (b) that mechanisms other than mutation or deletion can down-regulate expression of the p16/CDKN2 gene; and (c) that the balance between CDK4 and its cognate inhibitor, P16INK4, may confer a cell growth advantage and facilitate tumor progression. 7728764 1995