CDK2, cyclin dependent kinase 2, 1017

N. diseases: 270; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.380 Biomarker disease BEFREE PEITC may induce G0/G1 cell-cycle arrest through affecting the proteins such as cdk2, cyclin E, and p21 in GBM 8401 cells. 26678675 2017
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.380 Biomarker disease BEFREE Thus, two distinct RNA-based mechanisms activate this novel KAP/ROCK2/Cdk2-dependent invasion pathway in glioblastoma. 24704824 2015
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.380 AlteredExpression disease BEFREE It targets CDK2, 7 and 9 preferentially, which are also overexpressed in glioblastoma. 26151768 2015
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.380 Biomarker disease BEFREE Further analysis showed that NRAS and CDK2 were positively related with GBM. 24967941 2014
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.380 GeneticVariation disease BEFREE CDKN2 deletions occurred in GBM from patients somewhat older than those patients with GBM lacking CDKN2 deletion (mean age 53 vs. 48 years). 9217972 1997
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.380 GeneticVariation disease BEFREE Using a comparative multiplex PCR assay, homozygous deletions of the CDKN2/p16 gene were detected in 5 anaplastic astrocytomas (25%) and 6 GBMs (46%), but in none of the lower-grade tumors. 8857999 1996
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.380 GeneticVariation disease BEFREE Thirty-six of 42 GBMs (86%) had alterations of either CDKN2/p16 (n = 22), RB (n = 10), or both (n = 4); these two genetic changes, however, were relatively exclusive (P = 0.003). 8548755 1996
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.380 Biomarker disease BEFREE These data support a role for MTS1/p16/CDKN2 as a tumor suppressor gene in the in vivo evolution of GBMs. 7887443 1995
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.380 GeneticVariation disease UNIPROT