CDK4, cyclin dependent kinase 4, 1019

N. diseases: 433; N. variants: 8
Disease: Malignant neoplasm of brain ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0153633
Disease: Malignant neoplasm of brain
Malignant neoplasm of brain 		0.320 Biomarker disease BEFREE Here, we test various combinations of highly selective and potent CDK4/6 inhibitors with commonly used cytotoxic drugs in several cancer cell lines derived from lung, breast and brain cancers, for their cell-killing effects as compared to monotherapy. 31600301 2019
CUI: C0153633
Disease: Malignant neoplasm of brain
Malignant neoplasm of brain 		0.320 Biomarker disease CTD_human Naringenin, a flavanone inhibits the proliferation of cerebrally implanted C6 glioma cells in rats. 20932960 2011
CUI: C0153633
Disease: Malignant neoplasm of brain
Malignant neoplasm of brain 		0.320 Biomarker disease BEFREE Alterations in P16ink4 or in the gene encoding one of its ligands, cyclin-dependent kinase 4 (CDK4), have been reported in human glioma cell lines and primary tumors but not in primitive neuroectodermal tumors (PNETs), the most common malignant brain tumor of childhood. 8847566 1996