CDK4, cyclin dependent kinase 4, 1019

N. diseases: 433; N. variants: 8
Disease: Neoplasms, Intracranial ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1527390
Disease: Neoplasms, Intracranial
Neoplasms, Intracranial 		0.310 Biomarker group BEFREE The drug caused rapid regression of Sonic hedgehog (SHH) and <i>MYC</i>-amplified group 3 medulloblastoma subcutaneous tumors and provided a highly significant survival advantage to mice bearing <i>MYC</i>-amplified intracranial tumors.<b>Conclusions:</b> Inhibition of CDK4/6 is potentially a highly effective strategy for the treatment of SHH and <i>MYC</i>-amplified group 3 medulloblastoma.<i></i>. 28637687 2017
CUI: C1527390
Disease: Neoplasms, Intracranial
Neoplasms, Intracranial 		0.310 Biomarker group CTD_human Naringenin, a flavanone inhibits the proliferation of cerebrally implanted C6 glioma cells in rats. 20932960 2011