CDK6, cyclin dependent kinase 6, 1021

N. diseases: 266; N. variants: 27
Disease: Glioblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.350 Biomarker disease BEFREE Changes of miR16 targeted genes, Bcl2 (B cell lymphoma 2), CDK6 (Cyclin-dependent kinase 6), CCND1 (cyclin D1), CCNE1 (cyclin E1) and SOX5 were confirmed in glioblastoma cell lines and tissue specimens. 28628119 2017
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.350 AlteredExpression disease BEFREE Pharmacological inhibition or small interfering NTSR1 treatment blocked glioblastoma cell cycle progression in the G1 phase with a concomitantly decreased expression of CDK6, CDK4, and c-Myc. 26180082 2016
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.350 Biomarker disease BEFREE Thus, SUMO1-CDK6 conjugation constitutes a mechanism of cell cycle control and inhibition of this SUMOylation pathway may provide a strategy for treatment of glioblastoma. 24953629 2014
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.350 AlteredExpression disease BEFREE MicroRNA (miR)-124 inhibits expression of CDK6 and prevents proliferation of glioblastoma and medulloblastoma cells in vitro. 23172372 2013
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.350 Biomarker disease CTD_human Pattern of retinoblastoma pathway inactivation dictates response to CDK4/6 inhibition in GBM. 20534551 2010
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.350 Biomarker disease BEFREE Expression of p19INK4d, CDK4, CDK6 in glioblastoma multiforme. 10884881 2000