|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
O'Donovan, Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia, Proc.Natl.Acad.Sci.
|
19477230 |
2009 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
To obtain independent support for this association, we sought evidence for genetic interaction between OLIG2 and three genes of relevance to oligodendrocyte function for which we have reported evidence for association with schizophrenia: CNP, NRG1, and ERBB4.
|
16891421 |
2006 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To obtain independent support for this association, we sought evidence for genetic interaction between OLIG2 and three genes of relevance to oligodendrocyte function for which we have reported evidence for association with schizophrenia: CNP, NRG1, and ERBB4.
|
16891421 |
2006 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association of rs1059004 polymorphism in the OLIG2 locus with whole-brain functional connectivity in first-episode schizophrenia.
|
31785364 |
2020 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
The results provide further evidence that the SNP rs762178 in OLIG2 seems to be a potential candidate in altering risk for schizophrenia in the Chinese Han population and worthy of further replication and functional study.
|
17934761 |
2008 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The results provide further evidence that the SNP rs762178 in OLIG2 seems to be a potential candidate in altering risk for schizophrenia in the Chinese Han population and worthy of further replication and functional study.
|
17934761 |
2008 |
|
Psychotic Disorders
|
0.310 |
GeneticVariation
|
group |
BEFREE |
Evidence that variation in the oligodendrocyte lineage transcription factor 2 (OLIG2) gene is associated with psychosis in Alzheimer's disease.
|
19477230 |
2009 |
|
Nonorganic psychosis
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
Evidence that variation in the oligodendrocyte lineage transcription factor 2 (OLIG2) gene is associated with psychosis in Alzheimer's disease.
|
19477230 |
2009 |
|
Glioblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
High expression of proneural gene OLIG2 without EGFRvIII expression may be associated with a favorable clinical outcome; however, IDH1/2 gene status and the extent of LOH regions may indicate that this small subgroup of GBM is a distinct genetic subgroup from oligodendroglial tumors.
|
22736234 |
2012 |
|
Glioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Previous data suggest that expression of transcription factors FoxG1 and Olig-2 can separate hotspot histone H3 family member 3A (H3F3A)-mutant tumours in paediatric glioma.
|
29053887 |
2018 |
|
Glioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition, tumor-bearing animals expressing mutant Idh1 displayed a prolonged survival and also overexpressed Olig2, features consistent with IDH1-mutated human gliomas.
|
28148827 |
2017 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The tumor was positive for OLIG2 and GFAP and negative for BRAF V600E and IDH1 R132H mutant protein immunostains.
|
29141672 |
2017 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Olig2 deletion causes a tumor phenotypic shift from an oligodendrocyte precursor-correlated proneural toward an astroglia-associated gene expression pattern, manifest in downregulation of platelet-derived growth factor receptor-α and reciprocal upregulation of epidermal growth factor receptor (EGFR).
|
27165742 |
2016 |
|
Glioblastoma Multiforme
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
High expression of proneural gene OLIG2 without EGFRvIII expression may be associated with a favorable clinical outcome; however, IDH1/2 gene status and the extent of LOH regions may indicate that this small subgroup of GBM is a distinct genetic subgroup from oligodendroglial tumors.
|
22736234 |
2012 |
|
Obsessive-Compulsive Disorder
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Five SNPs achieved 0.004 (the nominal p-value expected by chance), 3 with empirical significant p-values (rs10070190 (CDH9) p = 1 × 10(-3), rs4825476 (GRIA3) p = 4 × 10(-4), and rs1074815 (TPH2) p = 8 × 10(-4)) and 2 additional polymorphisms showing nominal significance (rs2834070 (OLIG2) p = 2 × 10(-3) and rs11783752 (SCL18A1) p = 3 × 10(-3)), were found to be related to both AN and OCD.
|
23337130 |
2013 |
|
Obsessive-Compulsive Disorder
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
The present study is the first to verify the associations of SNPs rs762178, rs1059004, and rs9653711 of the OLIG2 gene with OCD in a Chinese Han population.
|
26271930 |
2015 |
|
Pilocytic Astrocytoma
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
These tumors expressed GFAP (5/6), OLIG2 (2/3), and S100 (1/1), and the pilocytic astrocytoma was negative for BRAF (V600E) mutant protein.
|
30074494 |
2018 |
|
Medulloblastoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In contrast to the prototype targeted Smo antagonist, HhAntag (Genentech), NanoHHI markedly inhibits the growth of allografts derived from Ptch(-/+); Trp53(-/-) mouse medulloblastomas that harbor a Smo(D477G) binding site mutation (P < 0.001), which is accompanied by significant downregulation of mGli1 as well as bona fide Hh target genes (Akna, Cltb, and Olig2).
|
22027695 |
2012 |
|
Abnormal behavior
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
Using diffusion tensor imaging, we examined the effect of a single nucleotide polymorphism (rs1059004) in OLIG2 previously associated with reduced gene expression, and with psychiatric disorders on fractional anisotropy in 78 healthy subjects.
|
22505278 |
2013 |
|
Adult Pilocytic Astrocytoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
These tumors expressed GFAP (5/6), OLIG2 (2/3), and S100 (1/1), and the pilocytic astrocytoma was negative for BRAF (V600E) mutant protein.
|
30074494 |
2018 |
|
Childhood Pilocytic Astrocytoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
These tumors expressed GFAP (5/6), OLIG2 (2/3), and S100 (1/1), and the pilocytic astrocytoma was negative for BRAF (V600E) mutant protein.
|
30074494 |
2018 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 gene.
|
10737801 |
2000 |
|
Anorexia Nervosa
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Five SNPs achieved 0.004 (the nominal p-value expected by chance), 3 with empirical significant p-values (rs10070190 (CDH9) p = 1 × 10(-3), rs4825476 (GRIA3) p = 4 × 10(-4), and rs1074815 (TPH2) p = 8 × 10(-4)) and 2 additional polymorphisms showing nominal significance (rs2834070 (OLIG2) p = 2 × 10(-3) and rs11783752 (SCL18A1) p = 3 × 10(-3)), were found to be related to both AN and OCD.
|
23337130 |
2013 |
|
Mental disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Using diffusion tensor imaging, we examined the effect of a single nucleotide polymorphism (rs1059004) in OLIG2 previously associated with reduced gene expression, and with psychiatric disorders on fractional anisotropy in 78 healthy subjects.
|
22505278 |
2013 |
|
Cerebral Palsy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our results indicate that in the Han Chinese population, the polymorphisms of OLIG2 were associated with CP, especially in patients who had suffered HIE injury.
|
30178266 |
2019 |