Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.060 Biomarker disease BEFREE In summary, CASC2 competes with SPRY2 for miR-183 binding to rescue the expression of SPRY2 in PC cells, thus enhancing the sensitivity of PC cells to docetaxel through SPRY2 downstream ERK signaling pathway; CASC2 and SPRY2 might be novel adjuvants for docetaxel-based chemotherapy for PC. 29373811 2019
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.060 Biomarker disease BEFREE Taken together, these data indicated that the serum levels of miR-27a may be a novel and non-invasive biomarker for the diagnosis and prognosis of patients with PCa, and miR-27a/SPRY2 may be a therapeutic target for the treatment of PCa. 30250598 2018
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.060 GeneticVariation disease BEFREE A potential clinical significance of DAB2IP and SPRY2 transcript variants in prostate cancer. 30301636 2018
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.060 AlteredExpression disease BEFREE Furthermore, loss of SPRY2 expression correlates strongly with loss of PTEN and/or PP2A subunits in human prostate cancer. 23434594 2013
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.060 AlteredExpression disease BEFREE Concomitant down-regulation of SPRY1 and SPRY2 in prostate carcinoma. 16954433 2006
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.060 GeneticVariation disease BEFREE We therefore propose hSPRY2 as a potential tumour suppressor locus in CaP. 15735753 2005