Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.330 Biomarker disease BEFREE This is the first study that identifies CDKN1B as a low-penetrance gene in thyroid cancer, and specifically in FVPTC subtype. 20075119 2010
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.330 AlteredExpression disease BEFREE Here, we report that the enforced expression of miR-221 and miR-222 was able to reduce p27(Kip1) protein levels in thyroid carcinoma and HeLa cells in the absence of significant changes in specific p27(Kip1) mRNA levels. 17914108 2007
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.330 Biomarker disease GENOMICS_ENGLAND Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans. 17030811 2006
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.330 AlteredExpression disease BEFREE In conclusion, our findings demonstrate that inactivation of PTEN may play a role in the development of sporadic thyroid carcinomas and that one key target of PTEN suppressor activity is represented by the cyclin-dependent kinase inhibitor p27kip1. 10918569 2000