CDKN1B, cyclin dependent kinase inhibitor 1B, 1027

N. diseases: 454; N. variants: 20
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.390 Biomarker disease BEFREE Ovarian cancer has a poor prognosis due to its chemoresistance, and p27Kip1 (p27) has been implicated in tumor prognosis and drug-resistance. 27314502 2016
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.390 AlteredExpression disease BEFREE PubMed and Web of science were searched for studies evaluating expression of p27(kip1) and prognostic in ovarian cancer. 26198169 2016
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.390 AlteredExpression disease BEFREE Significantly decreased total and phosphorylated CDKN1B level was noted in OvCa with increased G6PC expression. 25926381 2015
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.390 GeneticVariation disease BEFREE The aim of this study was to investigate the potential prognostic value of SKP2, genes P27Kip1, K-ras, c-Myc, COX2 and HER2 genes expression in ovarian cancer. 26320455 2015
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.390 AlteredExpression disease BEFREE In addition, XPC and p27(Kip1) were down regulated by eIF3a. eIF3a improves ovarian cancer patients' response to DDP-based chemotherapy via down regulating XPC and p27(Kip1). 26213845 2015
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.390 GeneticVariation disease BEFREE The aim of the present study was to evaluate the role of SNPs in three genes, XRCC2 (R188H), ERCC2 (K751Q) and CDKN1B (V109G) which are with moderate risk for ovarian cancer susceptibility in Egyptian women. 23277402 2013
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.390 Biomarker disease CTD_human A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression. 16391232 2006
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.390 GeneticVariation disease LHGDN Effect of the cyclin-dependent kinases inhibitor p27 on resistance of ovarian cancer multicellular spheroids to anticancer chemotherapy. 15924242 2005
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.390 AlteredExpression disease BEFREE A negative correlation between Jab1 and p27(kip1) expression was found in both benign (P = 0.003) and malignant (P = 0.002) ovarian tumors. 11751512 2001
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.390 AlteredExpression disease BEFREE The results suggest that low expression of p27(kip1) and cyclin D1 as well as high expression of cyclin E and cdk2 promotes the development of ovarian tumors. p27(kip1) and cyclin D1 expression are negatively correlated with the malignant degree of epithelial ovarian tumors. 10329035 1999