FSTL3, follistatin like 3, 10272

N. diseases: 33; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0035435
Disease: Rheumatism
Rheumatism
0.010 Biomarker disease BEFREE As a result of this unique combination of the libraries and probes, we cloned follistatin-related protein (FRP) as a novel autoantigen in systemic rheumatic diseases. 9786430 1998
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.010 AlteredExpression group BEFREE The expression of NEDD8, calponin, and the follistatin-related protein in normal prostate tissues is a novel finding and the role of these important functional proteins in normal prostate and their loss or reduced expression in prostate malignancy warrants further investigations. 11757036 2002
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.010 AlteredExpression group BEFREE The expression of NEDD8, calponin, and the follistatin-related protein in normal prostate tissues is a novel finding and the role of these important functional proteins in normal prostate and their loss or reduced expression in prostate malignancy warrants further investigations. 11757036 2002
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.010 AlteredExpression disease BEFREE Follistatin-related protein gene (FRP) is expressed in the synovial tissues of rheumatoid arthritis, but its polymorphisms are not associated with genetic susceptibility. 15638044 2005
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation
0.020 AlteredExpression phenotype BEFREE Our results suggest that IGFBP1 and Follistatin-like 3 are highly up-regulated in IUGR in the placenta. 16338475 2006
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.010 AlteredExpression group LHGDN Expression levels of follistatin, follistatin-like 3, and activin subunits beta(A) as well as beta(E) were investigated in chemically induced rat and human liver tumours by real-time PCR and immunohistochemistry. 16935389 2006
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.030 AlteredExpression disease BEFREE Here, we show that activin-induced growth inhibition is altered in FLRG-expressing breast cancer lines. 17671190 2007
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.030 Biomarker disease BEFREE Finally, a strong expression of FLRG was observed in invasive breast carcinomas in contrast with the normal luminal epithelial cells in which FLRG was not detected. 17671190 2007
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation
0.020 Biomarker phenotype BEFREE Microarray experiments identified increased expression of certain genes including leptin, soluble vascular endothelial growth factor receptor, human chorionic gonadotropin, follistatin-like 3, and hypoxia-inducible factor 2alpha in the IUGR. 17240240 2007
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.020 Biomarker group BEFREE Our data provide strong evidence that endogenous FLRG contributes to tumor cell proliferation through antagonizing endogenous activin effects. 17671190 2007
CUI: C0013537
Disease: Eclampsia
Eclampsia
0.010 AlteredExpression disease BEFREE Overproduction of the follistatin-related gene protein in the placenta and maternal serum of women with pre-eclampsia. 17617189 2007
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.010 AlteredExpression group LHGDN Silencing of FLRG, an antagonist of activin, inhibits human breast tumor cell growth. 17671190 2007
CUI: C0018801
Disease: Heart failure
Heart failure
0.030 AlteredExpression disease BEFREE Real-time PCR revealed that FSTL1 and FSTL3 expression was elevated in heart failure but returned to normal after recovery. 18617621 2008
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.030 AlteredExpression disease BEFREE Real-time PCR revealed that FSTL1 and FSTL3 expression was elevated in heart failure but returned to normal after recovery. 18617621 2008
CUI: C0018801
Disease: Heart failure
Heart failure
0.030 AlteredExpression disease BEFREE FSTL3 expression is elevated in patients with heart failure and is upregulated in cardiomyocytes by hypertrophic stimuli, but its role in cardiac remodelling is largely unknown. 22915069 2012
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.030 AlteredExpression disease BEFREE FSTL3 expression is elevated in patients with heart failure and is upregulated in cardiomyocytes by hypertrophic stimuli, but its role in cardiac remodelling is largely unknown. 22915069 2012
CUI: C1397307
Disease: Cardiac fibrosis
Cardiac fibrosis
0.010 Biomarker disease BEFREE We found that FSTL3 is necessary for this response and for the induction of cardiac fibrosis. 22915069 2012
CUI: C3839507
Disease: Diminished ovarian reserve
Diminished ovarian reserve
0.010 Biomarker disease BEFREE Forty-eight transcripts were differentially expressed, including CXXC finger protein 5 (CXXC5), forkhead box C1 (FOXC1) (down-regulated in DOR) as well as connective tissue growth factor (CTGF), follistatin-like 3 (FSTL3), prostaglandin-endoperoxide synthase 2 (PTGS2) and suppressor of cytokine signaling 2 (SOCS2) (up-regulated in DOR). 22246450 2012
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis
0.020 Biomarker disease BEFREE Both FSTL3-knockout and FST288-only mice had extensive hepatic steatosis and elevated hepatic triglyceride content. 23533219 2013
CUI: C0015695
Disease: Fatty Liver
Fatty Liver
0.010 Biomarker disease BEFREE Both FSTL3-knockout and FST288-only mice had extensive hepatic steatosis and elevated hepatic triglyceride content. 23533219 2013
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.030 Biomarker disease BEFREE Here we evaluate FSTL3 as a prognostic tool and its relation with clinical and pathological features of breast cancer. 28178680 2017
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.030 Biomarker disease BEFREE Here we evaluate FSTL3 as a prognostic tool and its relation with clinical and pathological features of breast cancer. 28178680 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.020 Biomarker group BEFREE However, the intensity of FSTL3 immunostaining correlated inversely with tumor size (r = -0.366, p<0.001) and with nuclear grade (p<0.01). 28178680 2017
CUI: C0085207
Disease: Gestational Diabetes
Gestational Diabetes
0.010 AlteredExpression phenotype BEFREE There were no significant differences in serum FSTL3 levels (p = 0.578) between the GDM group and the GDM-free control group. 27623975 2017
CUI: C0853879
Disease: Invasive carcinoma of breast
Invasive carcinoma of breast
0.010 AlteredExpression disease BEFREE FSTL3 expression in invasive breast cancer is inversely associated with tumor size and nuclear grade but it does not predict disease relapse in the short term. 28178680 2017