FSTL3, follistatin like 3, 10272

N. diseases: 15; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018801
Disease: Heart failure
Heart failure
0.020 AlteredExpression disease BEFREE FSTL3 expression is elevated in patients with heart failure and is upregulated in cardiomyocytes by hypertrophic stimuli, but its role in cardiac remodelling is largely unknown. 22915069 2013
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.020 AlteredExpression disease BEFREE FSTL3 expression is elevated in patients with heart failure and is upregulated in cardiomyocytes by hypertrophic stimuli, but its role in cardiac remodelling is largely unknown. 22915069 2013
CUI: C0018801
Disease: Heart failure
Heart failure
0.020 AlteredExpression disease BEFREE Real-time PCR revealed that FSTL1 and FSTL3 expression was elevated in heart failure but returned to normal after recovery. 18617621 2009
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.020 AlteredExpression disease BEFREE Real-time PCR revealed that FSTL1 and FSTL3 expression was elevated in heart failure but returned to normal after recovery. 18617621 2009
CUI: C0853879
Disease: Invasive carcinoma of breast
Invasive carcinoma of breast
0.010 Biomarker disease BEFREE Prognostic value of follistatin-like 3 in human invasive breast cancer. 28178680 2018
CUI: C1565489
Disease: Renal Insufficiency
Renal Insufficiency
0.010 Biomarker disease BEFREE FSTL3 is increased in renal dysfunction. 28339962 2018
CUI: C0015695
Disease: Fatty Liver
Fatty Liver
0.010 Biomarker disease BEFREE Both FSTL3-knockout and FST288-only mice had extensive hepatic steatosis and elevated hepatic triglyceride content. 23533219 2013
CUI: C1397307
Disease: Cardiac fibrosis
Cardiac fibrosis
0.010 Biomarker disease BEFREE We found that FSTL3 is necessary for this response and for the induction of cardiac fibrosis. 22915069 2013
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis
0.010 Biomarker disease BEFREE Both FSTL3-knockout and FST288-only mice had extensive hepatic steatosis and elevated hepatic triglyceride content. 23533219 2013
CUI: C3839507
Disease: Diminished ovarian reserve
Diminished ovarian reserve
0.010 AlteredExpression disease BEFREE Forty-eight transcripts were differentially expressed, including CXXC finger protein 5 (CXXC5), forkhead box C1 (FOXC1) (down-regulated in DOR) as well as connective tissue growth factor (CTGF), follistatin-like 3 (FSTL3), prostaglandin-endoperoxide synthase 2 (PTGS2) and suppressor of cytokine signaling 2 (SOCS2) (up-regulated in DOR). 22246450 2012
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.010 AlteredExpression disease BEFREE Here, we show that activin-induced growth inhibition is altered in FLRG-expressing breast cancer lines. 17671190 2007
CUI: C0013537
Disease: Eclampsia
Eclampsia
0.010 AlteredExpression disease BEFREE Overproduction of the follistatin-related gene protein in the placenta and maternal serum of women with pre-eclampsia. 17617189 2007
CUI: C0028754
Disease: Obesity
Obesity
0.010 Biomarker disease BEFREE We found that homozygous FSTL3 knockout adults developed a distinct group of metabolic phenotypes, including increased pancreatic islet number and size, beta cell hyperplasia, decreased visceral fat mass, improved glucose tolerance, and enhanced insulin sensitivity, changes that might benefit obese, insulin-resistant patients. 17229845 2007
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.010 AlteredExpression disease BEFREE Finally, a strong expression of FLRG was observed in invasive breast carcinomas in contrast with the normal luminal epithelial cells in which FLRG was not detected. 17671190 2007
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.010 AlteredExpression group LHGDN Overexpression of FLRG, an antagonist of activin is associated with increased breast tumor cell growth 17671190 2007
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.010 AlteredExpression group LHGDN Follistatin-like 3 expression was low in normal but enhanced in malignant rat liver.in human normal liver, in contrast, it was abundantly expressed but downregulated in liver cancer 16935389 2006
CUI: C0035435
Disease: Rheumatism
Rheumatism
0.010 Biomarker disease BEFREE Cloning of follistatin-related protein as a novel autoantigen in systemic rheumatic diseases. 9786430 1998