|
Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Casein kinase 1 epsilon (<i>CK1ε</i>) gene expression plays a role in numerous cancers, and the knockdown of <i>CK1ε</i> induces tumor cell-selective cytotoxicity.
|
31602258 |
2019 |
|
Malignant neoplasm of mouth
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Impact of Polymorphisms in Casein Kinase 1 Epsilon and Environmental Factors in Oral Cancer Susceptibility.
|
31602258 |
2019 |
|
Lip and Oral Cavity Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Impact of Polymorphisms in Casein Kinase 1 Epsilon and Environmental Factors in Oral Cancer Susceptibility.
|
31602258 |
2019 |
|
Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Importantly, we also observed that REGγ depletion activated Hippo signaling pathway via stabilizing CK1ε in RCC, indicating the cross-talk between REGγ/CK1ε axis and Hippo pathway during RCC development.
|
29795381 |
2018 |
|
Ulcerative Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
An Inhibitor of Casein Kinase 1ε/δ (PF670462) Prevents the Deterioration of Dextran Sodium Sulfate-induced Ulcerative Colitis Caused by UVB Eye Irradiation.
|
29989105 |
2018 |
|
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In our previous work, we identified casein kinase 1 ε (CK1ε, also known as CSNK1E) as a potential survival factor in glioblastoma.
|
30206363 |
2018 |
|
Polycystic Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Casein kinase 1ε and 1α as novel players in polycystic kidney disease and mechanistic targets for (R)-roscovitine and (S)-CR8.
|
29537311 |
2018 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In our previous work, we identified casein kinase 1 ε (CK1ε, also known as CSNK1E) as a potential survival factor in glioblastoma.
|
30206363 |
2018 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Importantly, we also observed that REGγ depletion activated Hippo signaling pathway via stabilizing CK1ε in RCC, indicating the cross-talk between REGγ/CK1ε axis and Hippo pathway during RCC development.
|
29795381 |
2018 |
|
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In our previous work, we identified casein kinase 1 ε (CK1ε, also known as CSNK1E) as a potential survival factor in glioblastoma.
|
30206363 |
2018 |
|
Glioblastoma Multiforme
|
0.010 |
Biomarker
|
disease |
BEFREE |
In our previous work, we identified casein kinase 1 ε (CK1ε, also known as CSNK1E) as a potential survival factor in glioblastoma.
|
30206363 |
2018 |
|
Amyotrophic Lateral Sclerosis, Sporadic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Transcriptome-pathology correlation identified casein kinase 1ε (CSNK1E) mRNA as tightly correlated to levels of pTDP-43 in sALS patients.
|
29881994 |
2018 |
|
Adenoma
|
0.010 |
Biomarker
|
group |
BEFREE |
Using <i>in situ</i> hybridization, the expression of key clock genes, including period circadian protein homolog (<i>Per</i>) 1 and 2, cryptochrome 1 (<i>Cry1</i>), circadian locomoter output cycles protein kaput (<i>Clock</i>), brain and muscle ARNT-like protein 1 (<i>Bmal1</i>) and casein kinase 1ε (<i>CK1</i>ε) were retrospectively examined in 51 cases of colorectal carcinoma and 10 cases of adenoma.
|
29113166 |
2017 |
|
Amyotrophic Lateral Sclerosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
DDX3 and CK1ε positive cells were mainly distributed in the anterior horn of spinal cord and co-localized with neurons not with glial cells, suggesting that the altered expression of DDX3 and CK1ε was closely related to motor neuron degeneration of ALS.
|
29118923 |
2017 |
|
Motor neuron atrophy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
DDX3 and CK1ε positive cells were mainly distributed in the anterior horn of spinal cord and co-localized with neurons not with glial cells, suggesting that the altered expression of DDX3 and CK1ε was closely related to motor neuron degeneration of ALS.
|
29118923 |
2017 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In conclusion, our findings show that high expression of CK1ε is positively associated with the Dukes staging and depth of invasion in CRC patients, and knockdown of CK1ε suppresses the growth and invasion of CRC cells through inhibition of the wnt/β-catenin signaling, suggesting that CK1ε may serve as a promising therapeutic target for the treatment of CRC.
|
26122218 |
2015 |
|
Liver carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The present study aimed to investigate the effect of hypoxia on the expression of circadian rhythm genes in liver cancer cells and to identify the mechanisms underlying this effect in hepatocellular carcinoma (HCC).The HCC cell line, PLC/PRF/5. was treated with either a vehicle control or CoCl2 at 50, 100 or 200 µΜ for 24 h. Following treatment, the protein expression levels of hypoxia‑inducible factor (HIF)‑1α and HIF‑2α were detected by western blotting and the mRNA expression levels of circadian rhythm genes, including circadian locomotor output cycles kaput (Clock), brain and muscle Arnt‑like 1 (Bmal1), period (Per)1, Per2, Per3, cryptochrome (Cry)1, Cry2 and casein kinase Iε (CKIε), were detected by reverse transcription quantitative polymerase chain reaction (RT‑qPCR).
|
25591621 |
2015 |
|
Heroin Dependence
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
These findings point to a role for Csnk1ε polymorphisms in heroin dependence among the Han Chinese population and may be informative for future genetic or neurobiological studies on heroin dependence.
|
24338102 |
2014 |
|
Mammary Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
As CK1ε is highly expressed in breast tumors, these findings offer an initial rationale to explore CK1ε blockade as a therapeutic strategy to treat cancers driven by deregulated mRNA translation.
|
24247720 |
2014 |
|
Patent ductus arteriosus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Quantitative real-time polymerase chain reaction was used to examine the circadian clock genes (brain-muscle-like (Bmal)-ARNTL, circadian locomotor output cycles kaput (Clock), cryptochrome 1 (Cry1), cryptochrome 2 (Cry2), casein kinase 1ε (CK1ε), period 1 (Per1), period 2 (Per2), period 3 (Per3), timeless (Tim), and timeless-interacting protein (Tipin)) in PDA, as well as matching adjacent and benign tissue.
|
23254314 |
2013 |
|
PATENT DUCTUS ARTERIOSUS 1
|
0.010 |
Biomarker
|
disease |
BEFREE |
Quantitative real-time polymerase chain reaction was used to examine the circadian clock genes (brain-muscle-like (Bmal)-ARNTL, circadian locomotor output cycles kaput (Clock), cryptochrome 1 (Cry1), cryptochrome 2 (Cry2), casein kinase 1ε (CK1ε), period 1 (Per1), period 2 (Per2), period 3 (Per3), timeless (Tim), and timeless-interacting protein (Tipin)) in PDA, as well as matching adjacent and benign tissue.
|
23254314 |
2013 |
|
Schizophrenia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association between a casein kinase 1 ε gene polymorphism and schizophrenia in a Chinese Han population.
|
22367616 |
2012 |
|
Carcinogenesis
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Our results thus strongly support the conclusion that CKIepsilon mutations play important roles in breast carcinogenesis.
|
20979026 |
2010 |
|
Methamphetamine dependence
|
0.010 |
Biomarker
|
disease |
BEFREE |
Association study between casein kinase 1 epsilon gene and methamphetamine dependence.
|
18991847 |
2008 |
|
Delayed Sleep Phase Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
These results indicate that the N408 allele in CKIepsilon plays a protective role in the development of DSPS and N-24 through alteration of the enzyme activity.
|
15187983 |
2004 |