CDKN2A, cyclin dependent kinase inhibitor 2A, 1029

N. diseases: 1314; N. variants: 146
Disease: Vulvar Intraepithelial Neoplasia, Differentiated Type ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1335968
Disease: Vulvar Intraepithelial Neoplasia, Differentiated Type
Vulvar Intraepithelial Neoplasia, Differentiated Type 		0.030 AlteredExpression disease BEFREE High-risk HPV was detected in 11 (10.5%) differentiated vulvar intraepithelial neoplasia-associated vulvar squamous cell carcinoma but correlated with high p16(INK4A) expression in only one case. 19567503 2009
CUI: C1335968
Disease: Vulvar Intraepithelial Neoplasia, Differentiated Type
Vulvar Intraepithelial Neoplasia, Differentiated Type 		0.030 Biomarker disease BEFREE Positive p53 and negative p16 staining was seen in 4 (17%) cases histologically suggestive of DVIN. 29254796 2018
CUI: C1335968
Disease: Vulvar Intraepithelial Neoplasia, Differentiated Type
Vulvar Intraepithelial Neoplasia, Differentiated Type 		0.030 Biomarker disease BEFREE All 6 tumors were associated with HPV16 and were positive for both p16 and HPV mRNA, and p16 was also positive in the dVIN-like and LS-like lesions. 29505429 2018