|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
HPV 16 and/or 18 were detected in 156 (80%) tumors. p16 was positive in 186 (96%) carcinomas, but eight tumors (4%) were negative for p16 (seven squamous cell carcinomas, one adenocarcinoma); 5/8 caused by HPV 16 and/or 18.
|
31492932 |
2020 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Our data suggest a role for CDKN2A/B and FHIT in early progression of BE to dysplasia and adenocarcinoma that warrants future mechanistic research.
|
31001805 |
2019 |
|
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Immunocytochemical studies on PF cell blocks allow: (a) to distinguish mesothelioma from reactive mesothelial proliferations (e.g. loss of BAP1 nuclear expression, complemented by the demonstration of p16 deletion using fluorescence in situ hybridization, indicate mesothelioma); (b) to separate mesothelioma from adenocarcinoma (e.g. calretinin, CK 5/6, WT-1 and D2-40 are markers of mesothelioma, whereas CEA, EPCAM, TTF-1, napsin A, and claudin 4 are markers of carcinoma); and (c) to reveal tumor origin in pleural metastases of an unknown primary site (e.g.
|
30354850 |
2019 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
<b>Results:</b> p16 and p53 were detected in 50.7 and 57.3% of adenocarcinoma (ADCs; n = 75), and 35.2 and 63.6% of squamous cell carcinoma (n = 88).
|
31157548 |
2019 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Most endocervical adenocarcinomas are human papillomavirus (HPV)-related cancers associated with p16 immunostaining.
|
31014281 |
2019 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Stromal p16 expression was evaluated in endocervical adenocarcinomas, including usual-type endocervical adenocarcinoma (UEA), intestinal-type mucinous carcinoma (MC-I), and MC-G.
|
29848709 |
2018 |
|
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In addition, it was found that CDKN2A mutations are significantly more common in SqCLC than in adenocarcinoma.
|
30178167 |
2018 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
UPS10 ( p = 0.023) and p14ARF ( p = 0.007) expression were significantly decreased in adenocarcinoma in comparison with normal tissue.
|
30375264 |
2018 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
E6, p53 and p16 demonstrated significantly different expression levels in squamous epithelial tissue compared with adenocarcinomas.
|
29085443 |
2017 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Positive reactivity for p16 was significantly associated (P=0.001) with histological grade, and was more commonly expressed in squamous cell carcinoma than adenocarcinomas.
|
28454340 |
2017 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Synchronous lung cancers from 60 patients (42 with adenocarcinoma and 18 with squamous cell carcinoma), clinically considered to represent intrapulmonary metastases, were histologically subtyped according to the 2015 World Health Organization classification of lung tumors and subjected to genotypic analysis (KRAS, EGFR, BRAF, PIK3CA, ALK, MET and ROS1 in adenocarcinoma and PIK3CA and p16 in squamous cell carcinoma).
|
27080983 |
2016 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Our results showed two hypomethylated genes (CDKN2A and MGMT) and three hypermethylated genes (CDH13, RUNX3 and APC) in ACs compared with SCCs.
|
26862903 |
2016 |
|
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Loss of the gene that encodes p16 (Cdkn2a) was required for progression of IPMNs to pancreatic ductal adenocarcinomas in Acvr1b(flox/flox);LSL-Kras(G12D);Pdx1-Cre mice.
|
26408346 |
2016 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
To examine the CIMP in patients with pulmonary adenocarcinoma after a surgical resection, we performed methylation analysis of six genes (CCNA1, ACAN, GFRA1, EDARADD, MGC45800, and p16 (INK4A)) in 230 pulmonary adenocarcinoma cases using the SEQUENOM MassARRAY platform.
|
26867769 |
2016 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We used gene expression data and immunohistochemistry to examine cyclin D1 and p16 levels in patient-derived xenografts (PDX), and prostatic small-cell carcinoma and adenocarcinoma specimens.
|
26246306 |
2015 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The goal of this study was to investigate p53 and p16 expression, as well as HPV status, in a relatively large series of primary bladder adenocarcinomas.
|
24752337 |
2014 |
|
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
All the GNAS-mutated LEGHs were negative for HPV DNA and p16 expression, whereas all the GNAS-mutated adenocarcinomas were positive for HPV DNA and/or p16 expression, implicating GNAS mutations in the development of LEGH and a minor subset of HPV-related cervical adenocarcinomas.
|
24145653 |
2014 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Ninety-six cardia adenocarcinomas and 79 distal samples were analyzed for comparing p16(INK) (4a) -Rb expressions, INK4a/ARF deletion, and methylation using immunohistochemistry, polymerase chain reaction, and methylation-specific polymerase chain reaction.
|
25123601 |
2014 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We investigated the presence of HPV genome by in situ hybridization (ISH) and polymerase chain reaction (PCR) and P16 or Rb protein expression by immunohistochemistry (IHC) in 336 surgically resected primary NSCLC: 204 adenocarcinoma (AdC) and 132 squamous cell carcinoma (SqCC).
|
23254264 |
2013 |
|
Adenocarcinoma
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
In multivariate analysis, p16 hypermethylation was more prevalent in lung tumours from male than female patients (P = 0.018) and in squamous cell carcinomas than in adenocarcinomas (P = 0.025).
|
22217548 |
2012 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
The findings of this study improve our understanding of the role that chromosomal instability and alterations of tumor suppressor genes such as CDKN2A and oncogenes such as ERBB2 play in the progression of intestinal metaplasia to adenocarcinoma in patients with Barrett's esophagus.
|
21820152 |
2012 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
In SH, CpG island methylation frequencies of p16(INK4a) (0.0%) and RASSF1A (12.5%) were significantly lower than those in adenocarcinoma (29.4% and 38.2%, respectively); the frequencies of HOX D9, D11, and D13 gene methylation in SH were 37.5%, 33.3%, and 33.3%, respectively.
|
21649526 |
2011 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Loss of p16 expression was associated with poorer survival time for the entire cohort and for certain subgroups including men, age younger than 65 years, smokers, early tumor stage, adenocarcinoma, and large-cell carcinoma.
|
21857254 |
2011 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
AI and p16(ink4a) gene aberrant methylation may provide a potential universal biomarker for small-sized adenocarcinoma.
|
21073868 |
2011 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
SFRP2 and IGF2 DMR0 showed significant methylation changes at the adenomatous polyp stage, followed by the CIMP markers CDKN2A and hMLH1 at the adenocarcinoma stage.
|
21068132 |
2011 |