Squamous cell carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
All IPs and associated SCCs were negative for p16 and hrHPV. lrHPV RNA was detected in 5/42 (12%) cases, including 3/5 (60%) with associated SCC (P=0.009).
|
31743131 |
2020 |
Squamous cell carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
HPV 16 and/or 18 were detected in 156 (80%) tumors. p16 was positive in 186 (96%) carcinomas, but eight tumors (4%) were negative for p16 (seven squamous cell carcinomas, one adenocarcinoma); 5/8 caused by HPV 16 and/or 18.
|
31492932 |
2020 |
Squamous cell carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
This study investigated the immunohistochemical expression of retinoblastoma (RB) protein and p16 protein in 10 neuroendocrine carcinomas (NECs), in comparison to two mixed-type NECs; 28 squamous cell carcinomas (SCCs), and 12 carcinosarcomas (CSs) from patients with esophageal cancer.
|
30952735 |
2019 |
Squamous cell carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Samples from 100 OPSCC patients were analyzed using polymerase chain reaction (PCR) and p16 immunohistochemistry.
|
30594962 |
2019 |
Squamous cell carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
The results of this study demonstrate that Sec62/Ki67 and p16 Ki67 dual-staining cytology could be a promising adjunctive diagnostic tool for VIN and squamous cell carcinoma, in addition to standard histology.
|
30607586 |
2019 |
Squamous cell carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
In the clinical samples of HNSCC, high expression of TrkA and panTrk were more associated with oropharyngeal and p16 positive squamous cell carcinoma (SCC).
|
30360033 |
2019 |
Squamous cell carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Human papillomavirus and p16 in squamous cell carcinoma and intraepithelial neoplasia of the vagina.
|
30561092 |
2019 |
Squamous cell carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
The pathology databases were searched for all neck-mass FNAs diagnosed as squamous cell carcinoma from January 2010 to March 2019. p16 ICC was performed on cytology smears, and the percentage and intensity of p16-positive cells were assessed.
|
31246356 |
2019 |
Squamous cell carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The purpose of this study was to evaluate PD-L1, FGFR1, PIK3CA, PTEN, and p16 expression in squamous cell carcinoma (SCC) associated with emphysema/COPD.
|
31481045 |
2019 |
Squamous cell carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Clinical relevance and significance of programmed death-ligand 1 expression, tumor-infiltrating lymphocytes, and p16 status in sinonasal squamous cell carcinoma.
|
31190998 |
2019 |
Squamous cell carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Histological and immunochemical analysis revealed the presence of a dual architectural pattern squamous cell carcinoma with a p16 negative and a p16 positive component.
|
30552721 |
2019 |
Squamous cell carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
<b>Results:</b> p16 and p53 were detected in 50.7 and 57.3% of adenocarcinoma (ADCs; n = 75), and 35.2 and 63.6% of squamous cell carcinoma (n = 88).
|
31157548 |
2019 |
Squamous cell carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
All SCCs showed diffuse and intense p16 expression consistent with the presence of HPV.
|
29406447 |
2019 |
Squamous cell carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Comparison of P16 expression in OSCC tumors with different degrees of promoter methylation further suggest the relationship of methylation rate and down-regulation of P16 expression.
|
30511108 |
2019 |
Squamous cell carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
We retrospectively included 50 histologically confirmed p16 positive oropharyngeal squamous cell carcinomas (p16 positive immunostaining was defined by a strong staining in 70% or more of tumor cells).
|
29925856 |
2018 |
Squamous cell carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
We performed immunohistochemical studies using anti‑cyclin D1, anti‑cyclin E, anti‑pRb, anti‑p53, anti‑p16INK4a, and anti‑Ki‑67 antibodies in normal skin, psoriatic epidermal tissue, and squamous cell carcinoma (SCC) tissue.
|
29115643 |
2018 |
Squamous cell carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
CDKN2A mutation carriers presented more atypical naevi, multiple melanomas, and basal cell carcinoma, while non-carriers were more likely to have light-coloured hair, atypical naevi, and SCC.
|
29405243 |
2018 |
Squamous cell carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
A novel variant on chromosome 4p15.31 near the LCORL gene and an imputed rare variant intergenic between CDKN2A and IFNA8 on chromosome 9p21.3 were identified at a genome-wide level of significance for squamous cell carcinomas.
|
29924316 |
2018 |
Squamous cell carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
In this study, using 348 head and neck SCCs (126 OP SCCs and 222 non-OP SCCs), we evaluated diagnostic performances of different HPV tests in OP and non-OP SCCs: polymerase chain reaction, p16 immunostaining, in situ hybridization targeting DNA (DNA-CISH) and RNA (RNA-CISH), combined p16 + DNA-CISH, and combined p16 + RNA-CISH.
|
29684499 |
2018 |
Squamous cell carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
To evaluate the impact of HPV16 load (VL-the number of virus genome copies per cell) and P16 expression on prognosis of patients with squamous cell carcinomas (SCCs) of head and neck (HN).
|
29043437 |
2018 |
Squamous cell carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Cancer stage and pack-years, but not p16 or HPV, are relevant for survival in hypopharyngeal and laryngeal squamous cell carcinomas.
|
29744637 |
2018 |
Squamous cell carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
We evaluated SOX2 immunohistochemical expression in normal cervix, low-grade squamous intraepithelial lesion (LSIL) (mild squamous dysplasia), high-grade squamous intraepithelial lesion (HSIL) (moderate and severe dysplasia) and SCC of the cervix in comparison with p16 and Ki-67.
|
27490766 |
2018 |
Squamous cell carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Squamous lesions were screened with immunohistochemical markers p16 and Ki-67 to compare expression in conjunctival papillomas (n = 21) to papillomas with high-grade dysplasia, SCC in situ, and invasive SCC (n = 40).
|
29533279 |
2018 |
Squamous cell carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Specimens from 1470 OPSCC patients collected from 2000 to 2016 were analyzed using the status of HPV by polymerase chain reaction (PCR) and p16 immunohistochemistry.
|
30310820 |
2018 |
Squamous cell carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
p16(INK4a) status and survival benefit of EGFR inhibitors in head and neck squamous cell cancer: A systematic review and meta-analysis.
|
29548481 |
2018 |