Liver neoplasms
|
0.690 |
Biomarker
|
group |
BEFREE |
In this study, we demonstrated that necrosis-inducing peptide P16 kills human glioblastoma cancer cells and primary human hepatoma or renal cancer cells isolated from patients who had not responded to standard treatments.
|
31206614 |
2019 |
Liver neoplasms
|
0.690 |
Biomarker
|
group |
CTD_human |
Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer.
|
27064257 |
2016 |
Liver neoplasms
|
0.690 |
Biomarker
|
group |
BEFREE |
In summary, a senescence-inducing program was found in hepatocytes with increased β-catenin levels and a positive selection of hepatocytes lacking p16(INK4a), by epigenetic silencing, drives the development of liver tumors in mice with reduced APC expression (Apc(580S) mice).
|
25270420 |
2015 |
Liver neoplasms
|
0.690 |
PosttranslationalModification
|
group |
BEFREE |
Herein, we evaluated CDKN2A promoter methylation and p16 protein expression for the differentiation of hepatocellular carcinoma (HCC) from other liver tumors.
|
20569442 |
2010 |
Liver neoplasms
|
0.690 |
AlteredExpression
|
group |
BEFREE |
Intriguingly, we found no evidence that Bmi1 regulates Ink4A/Arf expression in both in vitro and in vivo systems of liver tumor development.
|
19934271 |
2009 |
Liver neoplasms
|
0.690 |
AlteredExpression
|
group |
BEFREE |
Lentiviral-mediated Smad4 RNAi induced anti-proliferation by p16 up-regulation and apoptosis by caspase 3 down-regulation in hepatoma SMMC-7721 cells.
|
18949401 |
2008 |
Liver neoplasms
|
0.690 |
Biomarker
|
group |
RGD |
Role of HSP90, CDC37, and CRM1 as modulators of P16(INK4A) activity in rat liver carcinogenesis and human liver cancer.
|
16317707 |
2005 |
Liver neoplasms
|
0.690 |
Biomarker
|
group |
CTD_human |
Role of HSP90, CDC37, and CRM1 as modulators of P16(INK4A) activity in rat liver carcinogenesis and human liver cancer.
|
16317707 |
2005 |
Liver neoplasms
|
0.690 |
AlteredExpression
|
group |
BEFREE |
Frequent p16ink4a inactivation is an early and frequent event of intraductal papillary neoplasm of the liver arising in hepatolithiasis.
|
15619210 |
2004 |
Liver neoplasms
|
0.690 |
Biomarker
|
group |
BEFREE |
Additionally, we analysed the methylation status of p16(INK4a) and other cancer-related genes in the same liver tumors.
|
12660822 |
2003 |
Liver neoplasms
|
0.690 |
Biomarker
|
group |
CTD_human |
Abnormalities of the ARF-p53 pathway in primary angiosarcomas of the liver.
|
12378512 |
2002 |
Liver neoplasms
|
0.690 |
Biomarker
|
group |
RGD |
De novo methylation of the p16INK4A gene in early preneoplastic liver and tumors induced by folate/methyl deficiency in rats.
|
12359353 |
2002 |
Liver neoplasms
|
0.690 |
Biomarker
|
group |
RGD |
Sequential changes in hepatocarcinogenesis induced by diethylnitrosamine plus thioacetamide in Fischer 344 rats: induction of gankyrin expression in liver fibrosis, pRB degradation in cirrhosis, and methylation of p16(INK4A) exon 1 in hepatocellular carcinoma.
|
11301474 |
2001 |
Liver neoplasms
|
0.690 |
GeneticVariation
|
group |
BEFREE |
p16INK4a and beta-catenin alterations in rat liver tumors induced by NNK.
|
11238187 |
2001 |
Liver neoplasms
|
0.690 |
Biomarker
|
group |
BEFREE |
There were no deletions of p16 and p15 in any of the hepatoma cell lines.
|
9058294 |
1997 |
Liver neoplasms
|
0.690 |
Biomarker
|
group |
HPO |
|
|
|