Malignant neoplasm of breast
|
0.520 |
AlteredExpression
|
disease |
BEFREE |
Panobinostat (LBH589) inhibits Wnt/β-catenin signaling pathway via upregulating APCL expression in breast cancer.
|
30880222 |
2019 |
Malignant neoplasm of breast
|
0.520 |
Biomarker
|
disease |
BEFREE |
The exact contribution of the Wnt-regulating proteins adenomatous polyposis coli (APC) and APC2 in the pathogenesis of human breast cancer are ill-defined, but our analysis of publically available array data sets indicates that tumors with concomitant low expression of both proteins occurs more frequently in the 'triple negative' phenotype, which is a subtype of breast cancer with particularly poor prognosis.
|
27694902 |
2017 |
Malignant neoplasm of breast
|
0.520 |
Biomarker
|
disease |
CTD_human |
Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis.
|
18507500 |
2008 |
Malignant neoplasm of breast
|
0.520 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
Global developmental delay
|
0.410 |
GeneticVariation
|
disease |
BEFREE |
Bi-allelic Loss of Human APC2, Encoding Adenomatous Polyposis Coli Protein 2, Leads to Lissencephaly, Subcortical Heterotopia, and Global Developmental Delay.
|
31585108 |
2019 |
Global developmental delay
|
0.410 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Directional neuronal migration is impaired in mice lacking adenomatous polyposis coli 2.
|
22573669 |
2012 |
Global developmental delay
|
0.410 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Directional neuronal migration is impaired in mice lacking adenomatous polyposis coli 2.
|
22573669 |
2012 |
Global developmental delay
|
0.410 |
Biomarker
|
disease |
HPO |
|
|
|
Seizures
|
0.400 |
Biomarker
|
phenotype |
GENOMICS_ENGLAND |
Directional neuronal migration is impaired in mice lacking adenomatous polyposis coli 2.
|
22573669 |
2012 |
Seizures
|
0.400 |
Biomarker
|
phenotype |
GENOMICS_ENGLAND |
Directional neuronal migration is impaired in mice lacking adenomatous polyposis coli 2.
|
22573669 |
2012 |
Intellectual Disability
|
0.400 |
Biomarker
|
group |
GENOMICS_ENGLAND |
Directional neuronal migration is impaired in mice lacking adenomatous polyposis coli 2.
|
22573669 |
2012 |
Intellectual Disability
|
0.400 |
Biomarker
|
group |
GENOMICS_ENGLAND |
Directional neuronal migration is impaired in mice lacking adenomatous polyposis coli 2.
|
22573669 |
2012 |
Seizures
|
0.400 |
Biomarker
|
phenotype |
HPO |
|
|
|
Intellectual Disability
|
0.400 |
Biomarker
|
group |
HPO |
|
|
|
Colorectal Carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
Collectively, the hsa_circ_0009361/miR-582/APC2 network could be employed as a potential therapeutic target for CRC patients.
|
31109967 |
2019 |
Colorectal Carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
This study indicates that APC2 is hypermethylated and may be a tumorigenesis biomarker for Chinese CRC patients.
|
30510602 |
2018 |
Colorectal Carcinoma
|
0.330 |
PosttranslationalModification
|
disease |
BEFREE |
These findings suggest a distinct molecular pathway for methylation of APC2, p14, and ECAD genes from those previously described for colorectal cancers with BRAF or KRAS mutations.
|
21455633 |
2011 |
Colorectal Carcinoma
|
0.330 |
Biomarker
|
disease |
CTD_human |
Genomic and epigenomic integration identifies a prognostic signature in colon cancer.
|
21278247 |
2011 |
Colorectal Carcinoma
|
0.330 |
Biomarker
|
disease |
CTD_human |
Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis.
|
18507500 |
2008 |
Colorectal Carcinoma
|
0.330 |
Biomarker
|
disease |
CTD_human |
Epigenetic regulation of WNT signaling pathway genes in inflammatory bowel disease (IBD) associated neoplasia.
|
18716850 |
2008 |
Breast Carcinoma
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
Panobinostat (LBH589) inhibits Wnt/β-catenin signaling pathway via upregulating APCL expression in breast cancer.
|
30880222 |
2019 |
Breast Carcinoma
|
0.320 |
Biomarker
|
disease |
BEFREE |
The exact contribution of the Wnt-regulating proteins adenomatous polyposis coli (APC) and APC2 in the pathogenesis of human breast cancer are ill-defined, but our analysis of publically available array data sets indicates that tumors with concomitant low expression of both proteins occurs more frequently in the 'triple negative' phenotype, which is a subtype of breast cancer with particularly poor prognosis.
|
27694902 |
2017 |
Breast Carcinoma
|
0.320 |
Biomarker
|
disease |
CTD_human |
Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis.
|
18507500 |
2008 |
Inflammatory Bowel Diseases
|
0.310 |
Biomarker
|
group |
CTD_human |
In the multivariate logistic regression model, methylation of APC1A and APC2 was more likely to be associated with IBD-associated neoplasia than IBD colitis.
|
18716850 |
2008 |
Inflammatory Bowel Diseases
|
0.310 |
Biomarker
|
group |
BEFREE |
In the multivariate logistic regression model, methylation of APC1A and APC2 was more likely to be associated with IBD-associated neoplasia than IBD colitis.
|
18716850 |
2008 |