|
Abetalipoproteinemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Thirty-nine of 43 blood samples (91%) sequentially collected from 12 patients with AML, ALL, or ABL showed p15 methylation status in excellent concordance with morphologic disease stage.
|
10706859 |
2000 |
|
Abnormality of the lymphatic system
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Acquired Immunodeficiency Syndrome
|
0.010 |
AlteredExpression
|
group |
BEFREE |
A segment of the gag gene of the human immunodeficiency virus (HIV) (HTLV-IIIB strain), the virus which causes acquired immunodeficiency syndrome (AIDS), has been cloned into the bacterial expression vector, pCQV2, and mapped to the right-hand portion of the gag gene containing the carboxyl-terminal portion of p24 and the amino-terminal portion of p15.
|
2449245 |
1988 |
|
ACTH-Secreting Pituitary Adenoma
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Actinic keratosis
|
0.010 |
Biomarker
|
disease |
LHGDN |
Genomic instability, mutations and expression analysis of the tumour suppressor genes p14(ARF), p15(INK4b), p16(INK4a) and p53 in actinic keratosis.
|
18331779 |
2008 |
|
Actinic keratosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Expression levels of the genes p14(ARF), p15(INK4b), p16(INK4a) and p53 were examined in 16 AKs and 12 SCCs by real-time RT-PCR.
|
18331779 |
2008 |
|
Acute biphenotypic leukemia
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
In nearly all French-American-British leukemia subtypes, we found p15 methylation in bone marrow or peripheral blood cells from 58% (46/79) of patients with acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), or acute biphenotypic leukemia (ABL).
|
10706859 |
2000 |
|
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Prognostic impact of p15 gene aberrations in acute leukemia.
|
27401303 |
2017 |
|
Acute leukemia
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Aberrant p15 promoter methylation in adult and childhood acute leukemias of nearly all morphologic subtypes: potential prognostic implications.
|
10706859 |
2000 |
|
Acute leukemia
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
In this study, the authors investigated the frequency and prognostic significance of p15 and p16 gene methylation in adult acute leukemia.
|
11413509 |
2001 |
|
Acute leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Reports on homozygous deletion of p16 and p15 genes suggest the value of larger, prospective studies with standardized treatment protocols to definitively establish the prognostic utility of p15/p16 deletions in acute leukemias.
|
10073286 |
1999 |
|
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that inactivation of p16 and p15 genes is one of the most common genetic events in acute leukemia, and plays an important role for the RB/p16 pathway in the pathogenesis of acute leukemia.
|
10634644 |
2000 |
|
Acute leukemia
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
To the best of our knowledge, this is the first report showing the possible association between P15(INK4B) promoter methylation and parvovirus B19 infection in acute leukemia.
|
18384396 |
2009 |
|
Acute leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that alterations of p16 and p15 genes are involved in a subset of acute leukemias with MLL gene rearrangement not only of lymphoid but also of myeloid phenotype.
|
9447829 |
1997 |
|
Acute leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These data show that inactivation of either the p15 or p16 gene by point mutation is a very uncommon event in acute leukaemias.
|
8616035 |
1996 |
|
Acute leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results demonstrate that CDK4I gene deletions are very frequent and probably early events in childhood acute leukaemias of lymphoid origin and especially in early-T and pre-B ALLs.
|
8555068 |
1995 |
|
Acute leukemia
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Cyclin-dependent kinase inhibitor p15 is frequently inactivated by either methylation or deletion in patients with acute leukemia.
|
15755508 |
2005 |
|
Acute leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Hypermethylation of CpG islands in the promoter region of the p15INK4B gene in childhood acute leukaemia.
|
15737564 |
2005 |
|
Acute leukemia
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
The frequency of p15(INK4B) gene methylation in newly diagnosed or relapsed AL was significantly higher than that in AL in the remission stage (P = 0.002) p15(INK4B) gene methylation was found in 5 of 13 (38%) low-risk MDS (RA/RAS) patients and 80% of them showed only partial methylation.
|
12150726 |
2002 |
|
Acute leukemia
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
The entire CpG island region of p15 was largely devoid of methylation in normal lymphocytes, but methylation of varying density was found in primary acute leukemia.
|
10498617 |
1999 |
|
Acute lymphocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Curcumin-Mediated Reversal of p15 Gene Promoter Methylation: Implication in Anti-Neoplastic Action against Acute Lymphoid Leukaemia Cell Line.
|
26333125 |
2015 |
|
Acute lymphocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiology.
|
26868379 |
2016 |
|
Acute lymphocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the cell lines, the homozygous deletion of the CDK4I gene was detected in a variety of cell lineages, whereas all 4 cases showing the homozygous deletion were confined to ALL.
|
7919362 |
1994 |
|
Acute lymphocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inactivation of the Ink4 gene locus locus on 9p comprising the tumour suppressor gene p16ink4a and its neighbours p14ARF and p15ink4b is common in childhood acute lymphoblastic leukaemia (ALL), but the prognostic significance is controversial.
|
12357355 |
2002 |
|
Acute lymphocytic leukemia
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
The methylation-specific polymerase chain reaction (MS-PCR) was used to analyze p15 and p16 gene methylation in 49 cases of acute lymphoblastic leukemia (ALL) and 29 cases of acute myelogenous leukemia (AML).
|
11413509 |
2001 |