CDKN2B, cyclin dependent kinase inhibitor 2B, 1030

N. diseases: 440; N. variants: 13
Disease: Glaucoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017601
Disease: Glaucoma
Glaucoma 		0.450 GeneticVariation disease BEFREE In conclusion, this meta-analysis indicates that CDKN2B gene rs1063192 polymorphism is significantly associated with a decreased risk of glaucoma. 28416752 2017
CUI: C0017601
Disease: Glaucoma
Glaucoma 		0.450 Biomarker disease BEFREE Many genome-wide association studies have identified common single nucleotide polymorphisms (SNPs) at the 9p21 glaucoma locus (CDKN2B/CDKN2B-AS1) to be significantly associated with primary open-angle glaucoma (POAG), with association being stronger in normal tension glaucoma (NTG) and advanced glaucoma. 27367510 2016
CUI: C0017601
Disease: Glaucoma
Glaucoma 		0.450 GeneticVariation disease BEFREE Our study was unable to confirm previous associations reported for variants in CDKN2B-AS1, CDKN2B, and SIX1 with any type of glaucoma. 25489222 2014
CUI: C0017601
Disease: Glaucoma
Glaucoma 		0.450 GeneticVariation disease GWASDB Common variants on chromosome 9p21 are associated with normal tension glaucoma. 22792221 2012
CUI: C0017601
Disease: Glaucoma
Glaucoma 		0.450 Biomarker disease CTD_human We also show that CDKN2A and CDKN2B are upregulated in the retina of a rat model of glaucoma. 21532571 2011
CUI: C0017601
Disease: Glaucoma
Glaucoma 		0.450 AlteredExpression disease BEFREE We also show that CDKN2A and CDKN2B are upregulated in the retina of a rat model of glaucoma. 21532571 2011
CUI: C0017601
Disease: Glaucoma
Glaucoma 		0.450 GeneticVariation disease GWASDB We also show that CDKN2A and CDKN2B are upregulated in the retina of a rat model of glaucoma. 21532571 2011
CUI: C0017601
Disease: Glaucoma
Glaucoma 		0.450 GeneticVariation disease BEFREE In conclusion, we found consistent evidence for three common variants (CDKN2B, ATOH7 and SIX1) significantly associated with glaucoma. 21427129 2011