CDKN2B, cyclin dependent kinase inhibitor 2B, 1030

N. diseases: 440; N. variants: 13
Disease: Mesothelioma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025500
Disease: Mesothelioma
Mesothelioma 		0.230 Biomarker disease RGD Homozygous deletion of CDKN2A/2B is a hallmark of iron-induced high-grade rat mesothelioma. 20065947 2010
CUI: C0025500
Disease: Mesothelioma
Mesothelioma 		0.230 PosttranslationalModification disease LHGDN Gene methylation in pleural mesothelioma: correlations with clinico-pathological features and patient's follow-up. 17920725 2008
CUI: C0025500
Disease: Mesothelioma
Mesothelioma 		0.230 Biomarker disease BEFREE We have found frequent inactivations of p16/Cdkn2a, p19/Arf (or P14/ARF) and p15/Cdkn2b, coinactivation of p16/Cdkn2a and p15/Cdkn2b and low rate of Trp53 mutations in both asb-Nf2(KO3/+) and asb-Nf2(+/+) mesothelioma cells. 16319530 2005
CUI: C0025500
Disease: Mesothelioma
Mesothelioma 		0.230 GeneticVariation disease BEFREE Codeletion of p15 and p16 was found in 72% of mesotheliomas, including all cases with spindle-cell components (n = 21) and total deletion of p15 and p16 was found in several mesotheliomas that lacked cytogenetic deletion of the chromosome 9 short arm. 7630635 1995