CDKN2B, cyclin dependent kinase inhibitor 2B, 1030

N. diseases: 440; N. variants: 13
Disease: Nevus ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027960
Disease: Nevus
Nevus 		0.120 Biomarker disease BEFREE This study determined whether decreased p15 levels represent a general biomarker for the transition from nevus to melanoma. 27855847 2016
CUI: C0027960
Disease: Nevus
Nevus 		0.120 AlteredExpression disease BEFREE Here, we show that CDKN2B is highly upregulated in benign melanocytic nevi, contributes to maintaining nevus melanocytes in a growth-arrested premalignant state, and is commonly lost in melanoma. 26183406 2015
CUI: C0027960
Disease: Nevus
Nevus 		0.120 Biomarker disease HPO