Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0262587
Disease: Parathyroid Adenoma
Parathyroid Adenoma
0.130 Biomarker disease BEFREE The present study revealed that ERK1/2 signalling pathway with up-regulation of HRAS, ARAF, and MEK1 genes and up-regulation of positive regulators of cell cycle (CCND1, CDK4, and E2F1) and down-regulation negative regulators of cell cycle (CDKN2A, CDKN2B, and RB1) made highly dysregulated MAPK signalling pathway in parathyroid adenoma. 31535356 2020
CUI: C0262587
Disease: Parathyroid Adenoma
Parathyroid Adenoma
0.130 PosttranslationalModification disease BEFREE Since cyclin-dependent kinase (CDK) inhibitors, CDKN2A and CDKN2B, and RASSF1A (Ras-association domain family 1, isoform A) are involved in G1-S phase arrest and act as potential tumor suppressor genes, we aimed to study potential methylation-mediated inactivation of these genes in parathyroid adenomas. 28600574 2017
CUI: C0262587
Disease: Parathyroid Adenoma
Parathyroid Adenoma
0.130 GeneticVariation disease BEFREE These observations indicate that inactivating mutations or homozygous deletions of the p16 and p15 genes occur uncommonly, if ever, in parathyroid adenomas; however, loss of a different tumor suppressor gene (or genes) on 9p appears to contribute to the pathogenesis of a significant percentage of these tumors. 8855819 1996
CUI: C0262587
Disease: Parathyroid Adenoma
Parathyroid Adenoma
0.130 Biomarker disease HPO