Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Psoriasis and psoriatic arthritis fall into this disease spectrum, with the largest region of susceptibility coming from the MHC (most likely HLA-C, ie, C*06:02 although additional influences are also being implicated), and most of the other genetic susceptibility coming from genes involved in cytokine production, specifically genes in the Th17 pathway (IL-12B, IL-23A and IL-23R, the latter, like in AS, not seen in Asians), genes in the nuclear factor κB pathway (TNFAIP3 and TNIP1) and genes in the Th2 pathway (IL-4 and IL-13).
|
21339218 |
2011 |
Malignant neoplasm of breast
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
Breast cancer tumorigenicity is dependent on high expression levels of NAF-1 and the lability of its Fe-S clusters.
|
27621439 |
2016 |
Breast Carcinoma
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
Breast cancer tumorigenicity is dependent on high expression levels of NAF-1 and the lability of its Fe-S clusters.
|
27621439 |
2016 |
Malignant neoplasm of breast
|
0.330 |
Biomarker
|
disease |
BEFREE |
NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth.
|
23959881 |
2013 |
Breast Carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth.
|
23959881 |
2013 |
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
NAF-1 and mNT are also implicated in a number of other human pathologies including diabetes, neurodegeneration and cardiovascular disease, as well as in development, differentiation and aging.
|
28426722 |
2017 |
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
NAF-1 and mNT are also implicated in a number of other human pathologies including diabetes, neurodegeneration and cardiovascular disease, as well as in development, differentiation and aging.
|
28426722 |
2017 |
Dermatologic disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
TNIP1 keratinocyte deficiency as reported for some skin diseases may predispose these cells to excessive inflammatory signalling upon exposure to viral or bacterial ligands for TLR.
|
29413846 |
2018 |
Kidney Failure, Chronic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
TNIP1 SNP (rs7708392) might be used to identify patients at risk of developing LN, which could help in early detection and treatment before progression to end-stage renal disease, improving patients' outcome and quality of life.
|
29589214 |
2018 |
Chronic kidney disease stage 5
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
TNIP1 SNP (rs7708392) might be used to identify patients at risk of developing LN, which could help in early detection and treatment before progression to end-stage renal disease, improving patients' outcome and quality of life.
|
29589214 |
2018 |
Hepatitis B
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
TNIP1 Polymorphisms with the Risk of Hepatocellular Carcinoma Based on Chronic Hepatitis B Infection in Chinese Han Population.
|
30073579 |
2019 |
Hepatitis B, Chronic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
TNIP1 Polymorphisms with the Risk of Hepatocellular Carcinoma Based on Chronic Hepatitis B Infection in Chinese Han Population.
|
30073579 |
2019 |
Primary Sjögren's syndrome
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
A TNIP1 risk haplotype was associated with antibody-positive primary SS (P = 5.7 × 10(-3) , OR = 1.47, 95%CI: 1.12-1.92).
|
23944604 |
2013 |
Uveomeningoencephalitic Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A TNIP1 polymorphism may be a risk factor for VKH syndrome in Han Chinese.
|
24788730 |
2014 |
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A case-control association study was conducted on the TNIP1 single nucleotide polymorphism (SNP) rs7708392 in 364 Japanese SLE patients, 553 RA patients and 513 healthy controls.
|
20849588 |
2010 |
Psoriasis
|
0.500 |
Biomarker
|
disease |
CTD_human |
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
|
20953190 |
2010 |
Pustulosis of Palms and Soles
|
0.300 |
Biomarker
|
disease |
CTD_human |
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
|
20953190 |
2010 |
Psoriasis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
A growing number of references have implicated TNIP1 through GWAS and expression studies in chronic inflammatory diseases such as psoriasis and rheumatoid arthritis, although TNIP1s exact role has yet been determined.
|
22542476 |
2012 |
Rheumatoid Arthritis
|
0.140 |
AlteredExpression
|
disease |
BEFREE |
A growing number of references have implicated TNIP1 through GWAS and expression studies in chronic inflammatory diseases such as psoriasis and rheumatoid arthritis, although TNIP1s exact role has yet been determined.
|
22542476 |
2012 |
Libman-Sacks Disease
|
0.300 |
Biomarker
|
disease |
CTD_human |
A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.
|
19838195 |
2009 |
Malignant neoplasm of breast
|
0.330 |
Biomarker
|
disease |
BEFREE |
A peptide corresponding to the iASPP 764-780 sequence stabilized the NAF-1 cluster, inhibited NAF-1 interaction with iASPP, and inhibited staurosporine-induced apoptosis activation in human breast cancer, as well as in PC-3 prostate cancer cells in which p53 is inactive.
|
30774867 |
2019 |
Breast Carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
A peptide corresponding to the iASPP 764-780 sequence stabilized the NAF-1 cluster, inhibited NAF-1 interaction with iASPP, and inhibited staurosporine-induced apoptosis activation in human breast cancer, as well as in PC-3 prostate cancer cells in which p53 is inactive.
|
30774867 |
2019 |
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
|
23740937 |
2013 |
Systemic Scleroderma
|
0.440 |
GeneticVariation
|
disease |
GWASDB |
A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
|
23740937 |
2013 |
Systemic Scleroderma
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
|
23740937 |
2013 |