Brain Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
CACNG2 (TARPγ2, Stargazin) is a multi-functional regulator of excitatory neurotransmission and has been implicated in the pathological processes of several brain diseases.
|
30478755 |
2019 |
Malignant neoplasm of breast
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Chronic postmastectomy pain (PMP) imposes a major burden on the quality of life of the ever-increasing number of long-term survivors of breast cancer.An earlier report by Nissenbaum et al. claimed that particular polymorphisms in the gene CACNG2 are associated with the risk of developing chronic PMP after breast surgery (Nissenbaum J, Devor M, Seltzer Z, Gebauer M, Michaelis M, Tal M, Dorfman R, Abitbul-Yarkoni M, Lu Y, Elahipanah T, delCanho S, Minert A, Fried K, Persson AK, Shpigler H, Shabo E, Yakir B, Pisante A, Darvasi A. Susceptibility to chronic pain following nerve injury is genetically affected by CACNG2.Genome Res 2010;20:1180-90).
|
30371558 |
2019 |
Breast Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Chronic postmastectomy pain (PMP) imposes a major burden on the quality of life of the ever-increasing number of long-term survivors of breast cancer.An earlier report by Nissenbaum et al. claimed that particular polymorphisms in the gene CACNG2 are associated with the risk of developing chronic PMP after breast surgery (Nissenbaum J, Devor M, Seltzer Z, Gebauer M, Michaelis M, Tal M, Dorfman R, Abitbul-Yarkoni M, Lu Y, Elahipanah T, delCanho S, Minert A, Fried K, Persson AK, Shpigler H, Shabo E, Yakir B, Pisante A, Darvasi A. Susceptibility to chronic pain following nerve injury is genetically affected by CACNG2.Genome Res 2010;20:1180-90).
|
30371558 |
2019 |
Neurodegenerative Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
This work also demonstrates the importance of considering STG interactions when developing ampakines to treat neurodegenerative diseases in which AMPAergic signaling is compromised.
|
29330065 |
2018 |
Inflammatory pain
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Here we show that the TARP γ-2 (stargazin) is present in SDH neurons and is necessary in a form of inflammatory pain-induced plasticity, which involves an increase in the prevalence of synaptic calcium-permeable AMPARs.
|
28559374 |
2017 |
Attention Deficit Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Between-gene interactions including DAO*DISC1 , DAO*NRG1 and DAO*RASD2 and a within-gene interaction for CACNG2 were found among schizophrenia subjects with severe sustained attention deficits, suggesting a modifying effect of impaired neuropsychological functioning.
|
23555897 |
2013 |
Attention deficit hyperactivity disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Between-gene interactions including DAO*DISC1 , DAO*NRG1 and DAO*RASD2 and a within-gene interaction for CACNG2 were found among schizophrenia subjects with severe sustained attention deficits, suggesting a modifying effect of impaired neuropsychological functioning.
|
23555897 |
2013 |
Childhood T Acute Lymphoblastic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
MRD ≥ 10(-3) at TP2 constitutes the most important predictive factor for relapse in childhood T-ALL.
|
21719599 |
2011 |
Malignant Neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Finally, we showed that human CACNG2 polymorphisms are associated with chronic pain in a cohort of cancer patients who underwent breast surgery.
|
20688780 |
2010 |
Chronic pain
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Susceptibility to chronic pain following nerve injury is genetically affected by CACNG2.
|
20688780 |
2010 |
Primary malignant neoplasm
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Finally, we showed that human CACNG2 polymorphisms are associated with chronic pain in a cohort of cancer patients who underwent breast surgery.
|
20688780 |
2010 |
Borderline Personality Disorder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A 1.6-fold overexpression of Stargazin was observed in patients with BPD (P=0.000036).
|
18408563 |
2008 |
Bronchopulmonary Dysplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A 1.6-fold overexpression of Stargazin was observed in patients with BPD (P=0.000036).
|
18408563 |
2008 |
Epilepsy
|
0.010 |
Biomarker
|
disease |
BEFREE |
MAGI2 encodes the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 that interacts with Stargazin, a protein also associated with epilepsy in the stargazer mouse.
|
18565486 |
2008 |
Spinocerebellar Ataxia 10
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus CACNG2 is located proximal to the SCA10 recombinant interval.
|
10643919 |
2000 |