TUBB3, tubulin beta 3 class III, 10381

N. diseases: 259; N. variants: 25
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.390 Biomarker disease LHGDN Class III beta-tubulin overexpression is a prominent mechanism of paclitaxel resistance in ovarian cancer patients. 15671559 2005
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.390 Biomarker disease LHGDN Class III beta-tubulin overexpression is a marker of poor clinical outcome in advanced ovarian cancer patients. 16675570 2006
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.390 AlteredExpression disease BEFREE Taxol resistance among the different histological subtypes of ovarian cancer may be associated with the expression of class III beta-tubulin. 18317222 2008
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.390 Biomarker disease CTD_human Epigenetic modification is involved in aberrant expression of class III beta-tubulin, TUBB3, in ovarian cancer cells. 18497984 2008
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.390 PosttranslationalModification disease LHGDN Epigenetic modification is involved in aberrant expression of class III beta-tubulin, TUBB3, in ovarian cancer cells. 18497984 2008
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.390 AlteredExpression disease BEFREE The relationship between REST and TUBB3 expression and chemotherapy resistance, clinicopathological parameters, and prognosis of ovarian cancer was then determined. 22684772 2012
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.390 Biomarker disease BEFREE This study assessed the role of miR-200c as regulator of class III β-tubulin (TUBB3), a factor associated with drug-resistance and poor prognosis in ovarian cancer. 23394580 2013
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.390 AlteredExpression disease BEFREE This study investigated the role of Sox9 in the expression of TUBB3 gene, a marker of aggressiveness in ovarian cancer (OC), encoding βIII-tubulin protein. 24661907 2014
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.390 Biomarker disease BEFREE ROC-curve analysis showed a valuable diagnostic potential for serum anti-TUBB3 antibodies to identify OC patients with higher sensitivity and specificity (95.3% and 97.6%, respectively). 29448203 2018
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.390 Biomarker disease BEFREE TUBB3, ERCC1 and P-gp are involved in the occurrence and development of ovarian cancer and can be used as important indexes judging the severity of ovarian cancer, providing a reference for the occurrence and development of the disease in ovarian cancer patients in clinical practice. 30570863 2019