Malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
DLC-1 (deleted in liver cancer) gene is frequently deleted in hepatocellular carcinoma.
|
12813468 |
2003 |
Malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
DLC1 (deleted in liver cancer), a gene in this interval, has been proposed as a candidate tumor suppressor gene because of its homology (86% similarity) with rat p122 RhoGAP, which catalyzes the conversion of active GTP-bound rho complex to the inactive GDP-bound form, and thus suppresses Ras-mediated oncogenic transformation.
|
12873722 |
2003 |
Malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
DLC-1 may be a tumor suppressor gene in liver cancer as well as in other cancers.
|
9605766 |
1998 |
Malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
Combined, these studies provide information on the mechanism of DLC-1 function and regulation, and further support the role of DLC-1 tumor suppression in NSCLC.
|
17932950 |
2008 |
Malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
Consistent with the oncosuppressive function of DLC1 in several cancers, including prostate and liver cancer, transduction of 22Rv1 and 7703K cells with an Ad-DLC1 expression vector resulted in alterations of cell morphology, induction of apoptosis, and inhibition of cell proliferation, migration, and anchorage-independent growth.
|
20198346 |
2010 |
Malignant neoplasm of liver
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Further, the miRNA-target gene network analysis displayed that the deleted in liver cancer (DLC-1) gene, an important negative regulator for cell motility, was potentially targeted by several differentially expressed miRNAs in HBc-introduced cells.
|
28982593 |
2018 |
Malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we show that differentiation of white and brown adipocytes requires Deleted in Liver Cancer 1 (DLC1), a Rho GTPase Activating Protein (RhoGAP) previously studied for its function in liver cancer.
|
28358928 |
2017 |
Malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
One of the genes from this region that is expressed by our suppressed hybrids is a candidate tumour suppressor gene, DLC1 (deleted in liver cancer), which has homology to rat RhoGAP.
|
10649492 |
2000 |
Malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
The DLC-1 gene encoding a regulator of the Rho family of small GTPases is altered in breast, prostate, colon, and liver cancer and has several characteristics of a tumor suppressor gene.
|
12792785 |
2003 |
Malignant neoplasm of liver
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The deleted in liver cancer (DLC-1) gene at chromosome 8p21-22 is altered mainly by genomic deletion or aberrant promoter methylation in a large number of human cancers such as breast, liver, colon and prostate and is known to have an inhibitory effect on breast and liver tumor cell growth.
|
14661059 |
2004 |
Malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Rho GTPase-activating protein DLC1 is a tumor suppressor that is often deleted in liver cancer and downregulated in other cancers.
|
20861185 |
2010 |
Malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
The SH2 domain in tensin family member c-ten requires R474 to bind a RhoGAP called DLC-1 (deleted in liver cancer).
|
19826001 |
2009 |
Malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
Together, our findings indicate that complex formation between the DLC1 START domain and CAV-1 contributes to DLC1 tumor suppression via a RhoGAP-independent mechanism, and suggest that DLC1 inactivation probably contributes to cancer progression.
|
22693251 |
2012 |
Malignant neoplasm of liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Treatment with SAHA or TSA efficiently increased DLC1 expression in all lines, particularly in 22Rv1 cells, and activated the DLC1 promoter through the same Sp1 sites.
|
22425986 |
2012 |
Malignant neoplasm of liver
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We investigated the expression and deletion of DLC-1 (frequently deleted in liver cancer gene), first reported in 1998 and having a high homology with rat p122RhoGAP in hepatocellular carcinoma (HCC).
|
11118037 |
2000 |