Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 GeneticVariation disease BEFREE Further, the miRNA-target gene network analysis displayed that the deleted in liver cancer (DLC-1) gene, an important negative regulator for cell motility, was potentially targeted by several differentially expressed miRNAs in HBc-introduced cells. 28982593 2018
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 Biomarker disease BEFREE Here we show that differentiation of white and brown adipocytes requires Deleted in Liver Cancer 1 (DLC1), a Rho GTPase Activating Protein (RhoGAP) previously studied for its function in liver cancer. 28358928 2017
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 AlteredExpression disease BEFREE Treatment with SAHA or TSA efficiently increased DLC1 expression in all lines, particularly in 22Rv1 cells, and activated the DLC1 promoter through the same Sp1 sites. 22425986 2012
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 Biomarker disease BEFREE Together, our findings indicate that complex formation between the DLC1 START domain and CAV-1 contributes to DLC1 tumor suppression via a RhoGAP-independent mechanism, and suggest that DLC1 inactivation probably contributes to cancer progression. 22693251 2012
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 Biomarker disease BEFREE The Rho GTPase-activating protein DLC1 is a tumor suppressor that is often deleted in liver cancer and downregulated in other cancers. 20861185 2010
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 Biomarker disease BEFREE Consistent with the oncosuppressive function of DLC1 in several cancers, including prostate and liver cancer, transduction of 22Rv1 and 7703K cells with an Ad-DLC1 expression vector resulted in alterations of cell morphology, induction of apoptosis, and inhibition of cell proliferation, migration, and anchorage-independent growth. 20198346 2010
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 Biomarker disease BEFREE The SH2 domain in tensin family member c-ten requires R474 to bind a RhoGAP called DLC-1 (deleted in liver cancer). 19826001 2009
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 Biomarker disease BEFREE Combined, these studies provide information on the mechanism of DLC-1 function and regulation, and further support the role of DLC-1 tumor suppression in NSCLC. 17932950 2008
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 GeneticVariation disease BEFREE The deleted in liver cancer (DLC-1) gene at chromosome 8p21-22 is altered mainly by genomic deletion or aberrant promoter methylation in a large number of human cancers such as breast, liver, colon and prostate and is known to have an inhibitory effect on breast and liver tumor cell growth. 14661059 2004
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 Biomarker disease BEFREE The DLC-1 gene encoding a regulator of the Rho family of small GTPases is altered in breast, prostate, colon, and liver cancer and has several characteristics of a tumor suppressor gene. 12792785 2003
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 Biomarker disease BEFREE DLC1 (deleted in liver cancer), a gene in this interval, has been proposed as a candidate tumor suppressor gene because of its homology (86% similarity) with rat p122 RhoGAP, which catalyzes the conversion of active GTP-bound rho complex to the inactive GDP-bound form, and thus suppresses Ras-mediated oncogenic transformation. 12873722 2003
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 Biomarker disease BEFREE DLC-1 (deleted in liver cancer) gene is frequently deleted in hepatocellular carcinoma. 12813468 2003
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 Biomarker disease BEFREE One of the genes from this region that is expressed by our suppressed hybrids is a candidate tumour suppressor gene, DLC1 (deleted in liver cancer), which has homology to rat RhoGAP. 10649492 2000
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 GeneticVariation disease BEFREE We investigated the expression and deletion of DLC-1 (frequently deleted in liver cancer gene), first reported in 1998 and having a high homology with rat p122RhoGAP in hepatocellular carcinoma (HCC). 11118037 2000
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 Biomarker disease BEFREE DLC-1 may be a tumor suppressor gene in liver cancer as well as in other cancers. 9605766 1998