Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.030 Biomarker disease BEFREE Thus, PIAS3 may represent a promising lung cancer therapeutic target because of its p53-independent efficacy and its potential to synergize with Bcl-2 targeted inhibitors. 23959540 2014
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.030 AlteredExpression disease BEFREE Exposure of lung cancer cells to 5-azacytidine and trichostatin A results in a significant increase in PIAS3 mRNA and protein expression. 21497567 2011
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.030 Biomarker disease BEFREE In this study, we investigated for the first time the role of PIAS3 in modulating oncogenic EGFR-STAT3 signaling pathway in lung cancer and the anti-proliferative effect of using PIAS3 in conjunction with EGFR blockade in NSCLC. 19569236 2009