Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3553462
Disease: INFLUENZA, SEVERE, SUSCEPTIBILITY TO
INFLUENZA, SEVERE, SUSCEPTIBILITY TO 		0.100 SusceptibilityMutation phenotype CLINVAR
CUI: C0030305
Disease: Pancreatitis
Pancreatitis 		0.010 AlteredExpression disease BEFREE In vivo studies showed that IP15 is strongly activated in pancreas early during caerulein-induced pancreatitis. 15184081 2004
CUI: C0036117
Disease: Salmonella infections
Salmonella infections 		0.010 Biomarker group BEFREE IP15 was also induced in pancreas under systemic-lipopolysaccharide treatment and in intestine under Salmonella infection. 15184081 2004
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.060 Biomarker phenotype BEFREE Gene-expression profiling in Chinese patients with colon cancer by coupling experimental and bioinformatic genomewide gene-expression analyses: identification and validation of IFITM3 as a biomarker of early colon carcinogenesis. 18470904 2008
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.020 Biomarker disease BEFREE The data suggest that IFITM3 plays an important role in early colon cancer development. 18470904 2008
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.020 Biomarker group LHGDN Gene-expression profiling in Chinese patients with colon cancer by coupling experimental and bioinformatic genomewide gene-expression analyses: identification and validation of IFITM3 as a biomarker of early colon carcinogenesis. 18470904 2008
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.020 Biomarker disease BEFREE The data suggest that IFITM3 plays an important role in early colon cancer development. 18470904 2008
CUI: C0001430
Disease: Adenoma
Adenoma 		0.010 Biomarker group BEFREE It was found that there was a significant IFITM3 increase in adenoma as compared with that in normal colon tissue. 18470904 2008
CUI: C0021400
Disease: Influenza
Influenza 		0.400 Biomarker disease BEFREE Tetherin and IFITM3 are recently identified interferon-induced cellular proteins that restrict infections by retroviruses and filoviruses and of influenza virus and flaviviruses, respectively. 20943977 2010
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.100 Biomarker group BEFREE Taking advantage of this well-studied virus infection system, we show that although both tetherin and IFITM3 are plasma membrane proteins, tetherin inhibits virion particle release from infected cells, while IFITM3 disrupts an early event after endocytosis of virion particles but before primary transcription of incoming viral genomes. 20943977 2010
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.060 AlteredExpression phenotype BEFREE This work has shown for the first time that IFITM3 physically interacts with OPN and reduces OPN mRNA expression, which mediates cell adhesion, cell invasion, colony formation in soft agar and metastasis in a rat model system. 19901966 2010
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.060 AlteredExpression phenotype BEFREE This work has shown for the first time that IFITM3 physically interacts with OPN and reduces OPN mRNA expression, which mediates cell adhesion, cell invasion, colony formation in soft agar and metastasis in a rat model system. 19901966 2010
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.060 AlteredExpression phenotype BEFREE Knockdown of IFITM3 expression by a specific siRNA significantly suppressed the proliferation, colony formation, migration, and invasion of colon cancer cells in vitro and tumor growth and metastasis in a xenograft model. 21531817 2011
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 AlteredExpression group BEFREE IFITM3 expression in a tissue microarray of tumor and matched normal colon tissue specimens and lymph node metastasis specimens obtained from 203 patients with colon cancer was measured immunohistochemically. 21531817 2011
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.060 AlteredExpression phenotype BEFREE Knockdown of IFITM3 expression by a specific siRNA significantly suppressed the proliferation, colony formation, migration, and invasion of colon cancer cells in vitro and tumor growth and metastasis in a xenograft model. 21531817 2011
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.020 AlteredExpression disease BEFREE Restored expression of KLF4, a putative tumor suppressor, downregulated IFITM3 expression in colon cancer cells in vitro. 21531817 2011
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.020 AlteredExpression group BEFREE IFITM3 was expressed at higher levels in colon tumors and, particularly, nodal metastases than in normal colon tissue. 21531817 2011
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.020 AlteredExpression disease BEFREE Restored expression of KLF4, a putative tumor suppressor, downregulated IFITM3 expression in colon cancer cells in vitro. 21531817 2011
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm 		0.020 AlteredExpression group BEFREE IFITM3 was expressed at higher levels in colon tumors and, particularly, nodal metastases than in normal colon tissue. 21531817 2011
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.010 AlteredExpression disease BEFREE IFITM3, an IFN-inducible gene, is overexpressed in human colorectal cancer. 21531817 2011
CUI: C0025202
Disease: melanoma
melanoma 		0.010 PosttranslationalModification disease BEFREE Interferon-alpha induces reversible DNA demethylation of the interferon-induced transmembrane protein-3 core promoter in human melanoma cells. 21413873 2011
CUI: C0686619
Disease: Secondary malignant neoplasm of lymph node
Secondary malignant neoplasm of lymph node 		0.010 AlteredExpression disease BEFREE IFITM3 expression in a tissue microarray of tumor and matched normal colon tissue specimens and lymph node metastasis specimens obtained from 203 patients with colon cancer was measured immunohistochemically. 21531817 2011
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.010 AlteredExpression disease BEFREE IFITM3, an IFN-inducible gene, is overexpressed in human colorectal cancer. 21531817 2011
CUI: C0021400
Disease: Influenza
Influenza 		0.400 Biomarker disease BEFREE Together these data reveal that the action of a single intrinsic immune effector, IFITM3, profoundly alters the course of influenza virus infection in mouse and humans. 22446628 2012
CUI: C0021400
Disease: Influenza
Influenza 		0.400 Biomarker disease BEFREE S-palmitoylation and ubiquitination differentially regulate interferon-induced transmembrane protein 3 (IFITM3)-mediated resistance to influenza virus. 22511783 2012