|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Thus, viral infections upregulate IFITM3 in human platelets and MKs, and IFITM3 expression is associated with adverse clinical outcomes.
|
30723081 |
2019 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Up-regulation of IFITM3 on effector T cells protected these cells from virus infection and imparted a survival advantage at sites of virus infection.
|
30650117 |
2019 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Role of rhesus macaque IFITM3(2) in simian immunodeficiency virus infection of macaques.
|
31682595 |
2019 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
mTOR inhibitors lower an intrinsic barrier to virus infection mediated by IFITM3.
|
30301809 |
2018 |
|
Virus Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The IFITM3 allele (rs12252-C) was suggested as a population-based genetic risk factor for severe influenza virus infection by A(H1N1)pdm09.
|
28842783 |
2018 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Interferon-induced transmembrane protein 3 (IFITM3) is a restriction factor that can be induced by viral infection and interferons (IFNs).
|
28435159 |
2018 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Further results revealed that KBD elevated the protein expression of MAVS, which subsequently increased the IFN-β and IFITM3 protein levels, thereby helping to fight viral infections.
|
28314479 |
2017 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Interferon-induced transmembrane protein 3 (IFITM3) is a cellular endosome- and lysosome-localized protein that restricts numerous virus infections.
|
29079573 |
2017 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Viral disease in Ifitm3-/- mice was accompanied by elevated production of cytokines, most notably IL-6.
|
28240600 |
2017 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
IFITM3 and severe influenza virus infection. No evidence of genetic association.
|
27492307 |
2016 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
IFITM3 is essential for control of influenza virus infection in mice and humans.
|
25256397 |
2014 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
IFITM3 and susceptibility to respiratory viral infections in the community.
|
23997235 |
2014 |
|
Virus Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The SNP rs12252-C allele alters the function of interferon-induced transmembrane protein-3 increasing the disease severity of influenza virus infection in Caucasians, but the allele is rare.
|
23361009 |
2013 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Therefore, patients receiving antifungal therapy with clinical preparations of AmphoB may be functionally immunocompromised and thus more vulnerable to influenza, as well as other IFITM3-restricted viral infections.
|
24268777 |
2013 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Taking advantage of this well-studied virus infection system, we show that although both tetherin and IFITM3 are plasma membrane proteins, tetherin inhibits virion particle release from infected cells, while IFITM3 disrupts an early event after endocytosis of virion particles but before primary transcription of incoming viral genomes.
|
20943977 |
2010 |