YAP1, Yes associated protein 1, 10413

N. diseases: 374; N. variants: 15
Disease: Neuroblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.310 Biomarker disease CTD_human Recurrent alterations at relapse included mutations in the putative CHD5 neuroblastoma tumor suppressor, chromosome 9p losses, DOCK8 mutations, inactivating mutations in PTPN14 and a relapse-specific activity pattern for the PTPN14 target YAP. 26121086 2015
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.310 AlteredExpression disease BEFREE These findings underscore the importance of YAP activity in response to trametinib in RAS-driven neuroblastomas, as well as the potential for targeting YAP in a trametinib combination. 31672841 2019