|
Carcinogenesis
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
The data sets were divided into four compartments: (i) genes associated with carcinogenesis: in 14 studies, 1881 genes were extracted, 75 genes were identified in more than one study, and only 4 genes (PRKCBP1, SPON1, TACSTD1, and PTPRM) were identified in three studies.
|
18217975 |
2009 |
|
Degenerative polyarthritis
|
0.010 |
Biomarker
|
disease |
LHGDN |
F-spondin, a neuroregulatory protein, is up-regulated in osteoarthritis and regulates cartilage metabolism via TGF-beta activation.
|
18780763 |
2009 |
|
C-reactive protein measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network.
|
22228203 |
2012 |
|
Presenile dementia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The association of connectivity with the SPON1 variant at rs2618516 on chromosome 11 (11p15.2) reached connectome-wide, genome-wide significance after stringent statistical corrections were enforced, and it was replicated in an independent subsample. rs2618516 was shown to affect brain structure in an elderly population with varying degrees of dementia.
|
23471985 |
2013 |
|
Dementia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The association of connectivity with the SPON1 variant at rs2618516 on chromosome 11 (11p15.2) reached connectome-wide, genome-wide significance after stringent statistical corrections were enforced, and it was replicated in an independent subsample. rs2618516 was shown to affect brain structure in an elderly population with varying degrees of dementia.
|
23471985 |
2013 |
|
Alzheimer's Disease
|
0.120 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.
|
23535033 |
2014 |
|
Alzheimer's Disease
|
0.120 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.
|
23535033 |
2014 |
|
Alzheimer's Disease
|
0.120 |
Biomarker
|
disease |
BEFREE |
SPON1 has not been previously associated with AD risk, but is plausibly related because the gene product binds to the amyloid precursor protein and inhibits its cleavage by β-secretase.
|
23535033 |
2014 |
|
Mental deterioration
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
These data suggest that SPON1 may be associated with the differential rate of cognitive decline in AD.
|
23535033 |
2014 |
|
Impaired cognition
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data suggest that SPON1 may be associated with the differential rate of cognitive decline in AD.
|
23535033 |
2014 |
|
Cartilaginous exostosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Then we demonstrated that SPON1 was significantly up-regulated in 72 osteosarcoma specimens compared with benign osteochondroma samples and elevated SPON1 was positively correlated with MMP9 expression.
|
26032498 |
2015 |
|
Osteosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, our study provides evidence of the contributions of SPON1 and the Fak and Src signaling to the progression of osteosarcoma and suggests that this axis may represent a potential therapeutic target for osteosarcoma.
|
26032498 |
2015 |
|
Secondary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Meanwhile, suppression of SPON1 in KHOS cells resulted in decreased pulmonary metastasis in vivo.
|
26032498 |
2015 |
|
Metastatic osteosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Knockdown of SPON1 expression in two metastatic osteosarcoma cell lines, HKOS and KRIB, dramatically suppressed cell migration and invasion.
|
26032498 |
2015 |
|
Osteosarcoma of bone
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, our study provides evidence of the contributions of SPON1 and the Fak and Src signaling to the progression of osteosarcoma and suggests that this axis may represent a potential therapeutic target for osteosarcoma.
|
26032498 |
2015 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Treatment with recombinant SPON1 protein in two non-metastatic osteosarcoma cell lines, HOS and U2OS, significantly promoted cell migration and invasion in vitro.
|
26032498 |
2015 |
|
Childhood Osteosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, our study provides evidence of the contributions of SPON1 and the Fak and Src signaling to the progression of osteosarcoma and suggests that this axis may represent a potential therapeutic target for osteosarcoma.
|
26032498 |
2015 |
|
Cerebral atrophy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The genetics dataset yielded two subtypes of AD characterized mainly by the presence/absence of the apolipoprotein E (APOE) ε4 genotype, but also involving differential presence of risk alleles of CD2AP, SPON1 and LOC39095 SNPs that were associated with differences in the respective patterns of brain atrophy, especially in the precuneus.
|
26923371 |
2017 |
|
Brain atrophy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The genetics dataset yielded two subtypes of AD characterized mainly by the presence/absence of the apolipoprotein E (APOE) ε4 genotype, but also involving differential presence of risk alleles of CD2AP, SPON1 and LOC39095 SNPs that were associated with differences in the respective patterns of brain atrophy, especially in the precuneus.
|
26923371 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Using a shotgun proteomic approach, high-mobility-group protein B1 and spondin-1 were significantly increased in T2D aorta compared to control aorta, suggesting vascular inflammation and smooth muscle proliferation, respectively.
|
27796656 |
2017 |
|
High density lipoprotein measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.
|
28334899 |
2017 |
|
Vitamin D3 measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis.
|
28757204 |
2017 |
|
Vitamin D measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis.
|
28757204 |
2017 |
|
Heart failure
|
0.020 |
Biomarker
|
disease |
BEFREE |
In pooled analysis of both cohorts, higher levels of nine proteins were associated with incident heart failure after adjustment for established risk factors: growth differentiation factor 15 (GDF-15), T-cell immunoglobulin and mucin domain 1 (TIM-1), tumour necrosis factor-related apoptosis-inducing ligand receptor 2 (TRAIL-R2), spondin-1 (SPON1), matrix metalloproteinase-12 (MMP-12), follistatin (FS), urokinase-type plasminogen activator surface receptor (U-PAR), osteoprotegerin (OPG), and suppression of tumorigenicity 2 (ST2).
|
28967680 |
2018 |
|
Congestive heart failure
|
0.020 |
Biomarker
|
disease |
BEFREE |
In pooled analysis of both cohorts, higher levels of nine proteins were associated with incident heart failure after adjustment for established risk factors: growth differentiation factor 15 (GDF-15), T-cell immunoglobulin and mucin domain 1 (TIM-1), tumour necrosis factor-related apoptosis-inducing ligand receptor 2 (TRAIL-R2), spondin-1 (SPON1), matrix metalloproteinase-12 (MMP-12), follistatin (FS), urokinase-type plasminogen activator surface receptor (U-PAR), osteoprotegerin (OPG), and suppression of tumorigenicity 2 (ST2).
|
28967680 |
2018 |