IFI30, IFI30 lysosomal thiol reductase, 10437

N. diseases: 28; N. variants: 1
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.050 AlteredExpression disease BEFREE GILT protein expression in melanocytes was induced in halo nevi, which are nevi undergoing immune-mediated regression, and is consistent with the association of GILT expression with improved survival in melanoma. 31591149 2019
CUI: C0025202
Disease: melanoma
melanoma 		0.050 Biomarker disease BEFREE GILT staining in antigen-presenting cells (APCs) was detected in 100% of primary and metastatic melanomas versus 31% of nevi, and it was typically intense. 26930048 2016
CUI: C0025202
Disease: melanoma
melanoma 		0.050 Biomarker disease LHGDN These data suggest that GILT-expressing melanoma cells could prove to be very promising for direct antigen presentation and CD4+ T cell recognition, and may have direct implications for the design of cancer vaccines. 18343923 2008
CUI: C0025202
Disease: melanoma
melanoma 		0.050 AlteredExpression disease BEFREE In contrast with professional APCs such as B cells, class II-positive human melanomas expressed relatively little to no GILT protein or mRNA. 15240658 2004
CUI: C0025202
Disease: melanoma
melanoma 		0.050 Biomarker disease LHGDN The absence of GILT in melanomas altered antigen processing and the hierarchy of immunodominant epitope presentation. 12021307 2002