CDX1, caudal type homeobox 1, 1044

N. diseases: 54; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.060 Biomarker disease BEFREE Cdx1 exerts a protective role in colon cancer stem cells, which play a crucial role in chemoresistance to paclitaxel through activation of autophagy. 23624503 2013
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.060 AlteredExpression disease BEFREE This inhibitory effect is dose-dependent and is observed in different colon cancer cell lines, and the degree of inhibition correlates with the ability of Cdx1 to reduce cell proliferation. 15215241 2004
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.060 Biomarker disease BEFREE Here we have analysed the pattern of Cdx1 in human colon cancer progression. 12970739 2003
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.060 AlteredExpression disease BEFREE This study tests the hypothesis that Cdx1 expression inhibits colon cancer cell proliferation by reducing cyclin D1 gene expression. 14508520 2003
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.060 AlteredExpression disease BEFREE CDX1 expression is developmentally and spatially regulated, and its expression is aberrantly down-regulated in colorectal cancers and colon cancer-derived cell lines. 12124393 2002
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.060 Biomarker disease BEFREE Deregulated expression of homeobox-containing genes, HOXB6, B8, C8, C9, and Cdx-1, in human colon cancer cell lines. 10833444 2000