CDX1, caudal type homeobox 1, 1044

N. diseases: 54; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.080 Biomarker phenotype BEFREE IMPLICATIONS: This study shows that CDX1 contributes to the tumorigenesis and progression of gastric cancer and suggests the potential of targeting CDX1 to treat this malignancy. 31416838 2019
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.080 Biomarker phenotype BEFREE Notably, the concomitant loss of Cdx1 led to a significant increase in the incidence of tumors in the distal colon, relative to APC(Min/+)-Cdx2 offspring, demonstrating a previously unrecognized role for this transcription factor in colorectal tumorigenesis. 25320087 2014
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.080 AlteredExpression phenotype BEFREE In conclusion, these functionally interacting events drive CDX1 expression and contribute to intestinal metaplasia, epithelial dedifferentiation, and carcinogenesis in the human stomach. 22749770 2012
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.080 AlteredExpression phenotype BEFREE Overall our findings show that downregulation of CDX1 and EphB receptor genes occurs independently and that different branches of epigenetic control systems including class I and III HDACs contribute to epigenetic silencing of Wnt/β-catenin targets during colorectal tumorigenesis. 21393996 2011
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.080 AlteredExpression phenotype BEFREE Given that Cdx1 has a pro-oncogenic function in vitro, the maintenance of a high level of expression in polyps, and even its overexpression in one-third of the specimens, suggest that this homeobox gene may be an important factor in the process toward malignant transformation during the first steps of tumorigenesis. 12970739 2003
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.080 GeneticVariation phenotype BEFREE Because the Cdx1 homeobox gene stimulates proliferation and induces transformation and tumorigenesis, it has been investigated whether it is involved in the complex network comprising p53, p21(WAF), and Bcl-2 in intestinal epithelial cells. 12270138 2002
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.080 AlteredExpression phenotype BEFREE We have previously described an inverse relationship between Cdx1 and Cdx2 mRNA levels and the extent of dysplasia and severity of clinical outcome in colorectal carcinoma, suggesting that altered expression of these genes was associated with colorectal carcinogenesis or tumor progression. 9593754 1998
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.080 AlteredExpression phenotype BEFREE It was concluded that decrease in human Cdx1 and/or Cdx2 expression is associated with colorectal tumorigenesis. 9036867 1997