|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Compared with CDX2, SATB2 and dual-positive staining for SATB2 and CDX2 both had higher specificities for signet ring cell carcinomas from the lower GI tract (81% vs. 49% and 86% vs. 49%, respectively, P<0.01 for both).
|
30212392 |
2018 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
CDX2 is routinely used for identifying gastrointestinal origin of metastatic adenocarcinomas; but a high percentage of other carcinomas also show positivity with this antibody.
|
29924451 |
2018 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, unlike what was seen with CDX2, none of the prostatic and lung carcinomas studied showed A33 positivity.
|
28226180 |
2017 |
|
Carcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
CDX2<sup>Null</sup>/BRAF<sup>V600E</sup> expression in adult mouse intestinal epithelium led to serrated morphology tumors (including carcinomas) and BRAF<sup>V600E</sup> potently interacted with CDX2 silencing to alter gene expression.
|
28072391 |
2017 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Compared with w/o.CDX2-assessment, w/.CDX2-assessment showed significantly fewer G-type carcinomas (P < 0.05).
|
28088838 |
2017 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The COX-2-expressing cells were scattered, not diffusely expressed, in gastric carcinomas from humans and Cdx2-transgenic mice.
|
25228975 |
2014 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Reduced expression of DSC1-3 was statistically linked to higher grading and DSC2, E-cadherin and CDX2 with shorter survival in high-grade carcinomas.
|
22438068 |
2012 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
CDX2 heterozygous mutant mice develop colonic polyps, and loss of CDX2 expression is seen in a subset of colon carcinomas in humans.
|
20699370 |
2010 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Besides intestinal tissues, expression of CDX2 has also been reported in various other epithelial tissues and carcinomas.
|
19795349 |
2009 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We examined the methylation statuses of 6 tumor-related genes, CDX2 (homeobox transcription factor), BMP-2 (bone morphogenetic protein 2), p16 (INK4A), CACNA2D3 (calcium channel-related), GATA-5 (transcription factor) and ER (estrogen receptor), in 106 primary gastric carcinomas by methylation-specific PCR and compared them with the past lifestyles of the patients.
|
19170207 |
2009 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Loss of CDX2 expression is seen in some poorly differentiated colon carcinomas in humans.
|
15825077 |
2005 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Reduction of Cdx2 expression is a feature of many human colon carcinomas and inactivation of one cdx2 allele facilitates the development of invasive adenocarcinoma in the murine colon.
|
16027724 |
2005 |
|
Carcinoma
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
We further examined the methylation status of CDX2 in primary gastric carcinomas by MSP and compared it with the past lifestyle of the patients, including dietary habits.
|
15498792 |
2005 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
CDX2 expression showed a relationship with expression of MUC2 (P<0.04) in the gallbladder carcinomas.
|
15645288 |
2005 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In conclusion, this work demonstrates that Cdx-2 activates the expression of MUC2 mucin gene in gastric cells, inducing an intestinal transdifferentiation phenotype that parallels what is observed both in intestinal metaplasia and some gastric carcinomas.
|
14525978 |
2003 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Prior studies indicate some human colon carcinomas also lack CDX2 expression.
|
12947088 |
2003 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Conversely, aberrant CDX2 expression is often seen in intestinal metaplasias in the stomach and esophagus and in some gastric carcinomas.
|
12404231 |
2002 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Loss of CDX2 expression and microsatellite instability are prominent features of large cell minimally differentiated carcinomas of the colon.
|
11733373 |
2001 |
|
Carcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We further examined 19 HNPCC carcinomas with microsatellite instability for mutations in a (G)7 repeat site within CDX2.
|
10027310 |
1999 |