CDX2, caudal type homeobox 2, 1045

N. diseases: 278; N. variants: 4
Disease: Colonic Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.360 Biomarker group CTD_human The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non-cell-autonomous mechanisms. 29439001 2018
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.360 AlteredExpression group LHGDN The intestine-specific homeobox gene Cdx2 decreases mobility and antagonizes dissemination of colon cancer cells. 17599044 2008
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.360 AlteredExpression group LHGDN Differential regulation of CDX1 and CDX2 gene expression by deficiency in methyl group donors. 18187048 2008
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.360 Biomarker group BEFREE CDX2 heterozygous-null mice develop colonic neoplasms, which have suggested that CDX2 is a tumor suppressor. 16314840 2006
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.360 AlteredExpression group LHGDN Cdx1 inhibits human colon cancer cell proliferation by reducing beta-catenin/T-cell factor transcriptional activity. 15215241 2004
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.360 AlteredExpression group LHGDN Silencing of CDX2 expression in colon cancer via a dominant repression pathway. 12947088 2003
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.360 AlteredExpression group BEFREE The CDX2 transcription factor is expressed in intestinal epithelium and is markedly down-regulated in colon tumours. 11161380 2001