Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Malignant neoplasm of colon and/or rectum
0.100 Biomarker disease BEFREE Digital image analysis of multiplex fluorescence IHC in colorectal cancer recognizes the prognostic value of CDX2 and its negative correlation with SOX2. 31641225 2020
Malignant neoplasm of colon and/or rectum
0.100 AlteredExpression disease BEFREE Combination of CDX2 expression and T stage improves prognostic prediction of colorectal cancer. 30616445 2019
Malignant neoplasm of colon and/or rectum
0.100 Biomarker disease BEFREE Pulmonary metastases of colorectal cancer were positive for CK20 in 83% and CDX2 in 99% of the cases. 30389437 2019
Malignant neoplasm of colon and/or rectum
0.100 Biomarker disease BEFREE MicroRNA-9-5p-CDX2 Axis: A Useful Prognostic Biomarker for Patients with Stage II/III Colorectal Cancer. 31783700 2019
Malignant neoplasm of colon and/or rectum
0.100 Biomarker disease BEFREE CDX2 in colorectal cancer is an independent prognostic factor and regulated by promoter methylation and histone deacetylation in tumors of the serrated pathway. 30257705 2018
Malignant neoplasm of colon and/or rectum
0.100 Biomarker disease BEFREE Prognostic, predictive, and pharmacogenomic assessments of CDX2 refine stratification of colorectal cancer. 29900672 2018
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation disease BEFREE Association of CDX2 Expression With Survival in Early Colorectal Cancer: A Systematic Review and Meta-analysis. 29519711 2018
Malignant neoplasm of colon and/or rectum
0.100 AlteredExpression disease BEFREE Loss of CDX2 gene expression is associated with DNA repair proteins and is a crucial member of the Wnt signaling pathway in liver metastasis of colorectal cancer. 29467879 2018
Malignant neoplasm of colon and/or rectum
0.100 PosttranslationalModification disease BEFREE Methylation of CDX2 gene promoter in the prediction of treatment efficacy in colorectal cancer. 29928401 2018
Malignant neoplasm of colon and/or rectum
0.100 Biomarker disease BEFREE The prognostic impact of CDX2 correlates with the underlying mismatch repair status and BRAF mutational status but not with distant metastasis in colorectal cancer. 29675807 2018
Malignant neoplasm of colon and/or rectum
0.100 AlteredExpression disease BEFREE Impact of CDX2 expression status on the survival of patients after curative resection for colorectal cancer liver metastasis. 30326864 2018
Malignant neoplasm of colon and/or rectum
0.100 Biomarker disease BEFREE Loss of caudal type homeobox 2 (CDX2) is associated with the development of human colorectal cancer, while human telomerase reverse transcriptase (hTERT) frequently occurs in variety of human cancers. 28627695 2017
Malignant neoplasm of colon and/or rectum
0.100 AlteredExpression disease BEFREE CDX2, a caudal-related homeobox transcription factor, represents a key tumor suppressor in colorectal cancer. 27754705 2016
Malignant neoplasm of colon and/or rectum
0.100 AlteredExpression disease BEFREE We previously reported that the Caudal-related homeobox transcription factor CDX2 transcriptionally regulates MDR1 expression in colorectal cancer. 27060927 2016
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation disease BEFREE This meta-analysis showed an overall increased risk of cancer associated with Cdx2 SNP and a specific higher risk of colorectal cancer associated with the TaqI polymorphism. 25738688 2016
Malignant neoplasm of colon and/or rectum
0.100 AlteredExpression disease BEFREE SOX2 expression is associated with a cancer stem cell state and down-regulation of CDX2 in colorectal cancer. 27411517 2016
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation disease BEFREE When stratified by different cancer types, significant association was observed between Cdx-2 variant and an increased risk of colorectal cancer in the homozygous, recessive, and dominant models. 26287424 2015
Malignant neoplasm of colon and/or rectum
0.100 Biomarker disease BEFREE These findings suggest that the Ascl2/CDX2 axis may serve as a potential therapeutic target in colorectal cancer. 26307678 2015
Malignant neoplasm of colon and/or rectum
0.100 AlteredExpression disease BEFREE Loss of CDX2 expression is associated with poor prognosis in colorectal cancer patients. 25663765 2015
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation disease BEFREE The aim of this study is to determine the specificity of Cdx2 protein expression and CpG promoter hypermethylation for BRAF(V600E) and high-level CIMP in colorectal cancer. 24166180 2014
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation disease BEFREE APC(Min/+)-Cdx2 mutants recapitulated several aspects of human colorectal cancer, including an invasive phenotype. 25320087 2014
Malignant neoplasm of colon and/or rectum
0.100 Biomarker disease BEFREE We furthermore identified the type of colorectal cancer by observing two positive peaks (20 bp for EpCAM and 30 bp for CDX2) in the μCE analysis. 24615960 2014
Malignant neoplasm of colon and/or rectum
0.100 AlteredExpression disease BEFREE Loss of CDX2/CK20 expression is associated with poorly differentiated carcinoma, the CpG island methylator phenotype, and adverse prognosis in microsatellite-unstable colorectal cancer. 24025523 2013
Malignant neoplasm of colon and/or rectum
0.100 Biomarker disease BEFREE Our findings challenge a prevailing view that CDX2 is a tumor suppressor in colorectal cancer and uncover an additional piece in the multistep model of colorectal tumorigenesis. 23112155 2012
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation disease BEFREE Five polymorphic variants of the VDR gene, including Cdx-2 (intron 1e) and FokI (exon 2) present in the 5' region of the gene, and BsmI (intron 8), ApaI (intron 8), and TaqI (exon 9) sites present in the 3' untranslated region (UTR), were evaluated for possible associations with colorectal cancer risk. 22529698 2012