ECI2, enoyl-CoA delta isomerase 2, 10455

N. diseases: 8; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.020 AlteredExpression disease BEFREE Expression levels of HNF1B and ECI2 proteins were validated by immunohistochemistry and western blotting at different stages of prostate cancer development. 30655870 2019
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.020 AlteredExpression disease BEFREE Expression levels of HNF1B and ECI2 proteins were validated by immunohistochemistry and western blotting at different stages of prostate cancer development. 30655870 2019
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.020 AlteredExpression disease BEFREE Increased ECI2 expression predicts mortality in prostate cancer patients (p = 0.0086). 28415728 2017
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.020 AlteredExpression disease BEFREE Increased ECI2 expression predicts mortality in prostate cancer patients (p = 0.0086). 28415728 2017
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.010 AlteredExpression phenotype BEFREE Taken together, these results demonstrated that upon tumor progression, the initial tumor-protective effect of HNF1B is lost along with downregulated expression of HNF1B and increased expression of ECI2. 30655870 2019
CUI: C0002874
Disease: Aplastic Anemia
Aplastic Anemia
0.010 Biomarker disease LHGDN Diazepam-binding inhibitor-related protein 1: a candidate autoantigen in acquired aplastic anemia patients harboring a minor population of paroxysmal nocturnal hemoglobinuria-type cells. 15217832 2004
CUI: C0002874
Disease: Aplastic Anemia
Aplastic Anemia
0.010 Biomarker disease BEFREE To identify candidate antigens in aplastic anemia (AA), we screened proteins derived from a leukemia cell line with serum of an AA patient and identified diazepam-binding inhibitor-related protein 1 (DRS-1). 15217832 2004
CUI: C0024790
Disease: Paroxysmal nocturnal hemoglobinuria
Paroxysmal nocturnal hemoglobinuria
0.010 Biomarker disease BEFREE Enzyme-linked immunosorbent assay (ELISA) revealed high titers of anti-DRS-1 antibodies (DRS-1 Abs) in 27 (38.0%) of 71 AA patients displaying increased paroxysmal nocturnal hemoglobinuria (PNH)-type cells (PNH(+)), 2 (6.3%) of 32 PNH(-) AA patients, 5 (38.5%) of 13 PNH(+) myelodysplastic syndrome (MDS) patients, and none of 42 PNH(-) MDS patients. 15217832 2004
CUI: C0271907
Disease: Acquired aplastic anemia
Acquired aplastic anemia
0.010 Biomarker disease BEFREE Diazepam-binding inhibitor-related protein 1: a candidate autoantigen in acquired aplastic anemia patients harboring a minor population of paroxysmal nocturnal hemoglobinuria-type cells. 15217832 2004
CUI: C3463824
Disease: MYELODYSPLASTIC SYNDROME
MYELODYSPLASTIC SYNDROME
0.010 Biomarker group BEFREE Enzyme-linked immunosorbent assay (ELISA) revealed high titers of anti-DRS-1 antibodies (DRS-1 Abs) in 27 (38.0%) of 71 AA patients displaying increased paroxysmal nocturnal hemoglobinuria (PNH)-type cells (PNH(+)), 2 (6.3%) of 32 PNH(-) AA patients, 5 (38.5%) of 13 PNH(+) myelodysplastic syndrome (MDS) patients, and none of 42 PNH(-) MDS patients. 15217832 2004
CUI: C0205734
Disease: Diabetes, Autoimmune
Diabetes, Autoimmune
0.010 Biomarker disease BEFREE Further studies are required to test whether or not DRS-1 is a new autoantigen in autoimmune diabetes. 10354522 1999