|
Red Blood Cell Count measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
High density lipoprotein measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels.
|
27036123 |
2016 |
|
Diastolic blood pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.
|
27841878 |
2017 |
|
Hormone refractory prostate cancer
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, all of EGFR, JAK2, NR3C1, PDZD2, and SEMA3C genes had single nucleotide polymorphisms (SNP) in castration-resistant prostate cancer, consistent with high selection pressure on these genes during drug treatment and consequent resistance.
|
30644608 |
2019 |
|
Colorectal Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Gains (GALNT6 and GALNT11) and losses (SEMA3C) involving the same gene families related to CRC susceptibility were found among the rare CNVs.
|
26620301 |
2016 |
|
Malaria
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
SCT and IL10 rs1800896, IL1A rs2856838, but not SEMA3C rs4461841, polymorphisms were associated with decreased risk of malaria in the controls.
|
29033373 |
2017 |
|
African Burkitt's lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Decreased risk of eBL was associated with IL10 rs1800896-CT (OR 0·73, 95% CI 0·50-1·07) and -CC genotypes (OR 0·53, 95% CI 0·29-0·95, p<sub>trend</sub>=0·019); IL1A rs2856838-AG (OR 0·56, 95% CI 0·39-0·81) and -AA genotype (OR 0·50, 95% CI 0·28-1·01, p<sub>trend</sub>=0·0016); and SEMA3C rs4461841-CT or -CC genotypes (OR 0·57, 95% CI 0·35-0·93, p=0·0193).
|
29033373 |
2017 |
|
Epilepsy, Rolandic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We also resequenced the SEMA3C gene at the 7q21 linkage locus in members of one multiplex RE/RD pedigree and the DISC1 gene in affected pedigrees at the 1q42 locus.
|
22815793 |
2012 |
|
Hirschsprung Disease
|
0.420 |
Biomarker
|
disease |
BEFREE |
To this end, we assessed the performance of the bench-top 454 GS Junior platform as an optimized solution for mutation detection by amplicon sequencing of three type 3 semaphorin genes SEMA3A, SEMA3C, and SEMA3D implicated in Hirschsprung disease (HSCR).
|
21898659 |
2012 |
|
Hirschsprung Disease
|
0.420 |
Biomarker
|
disease |
HPO |
|
|
|
|
Hirschsprung Disease
|
0.420 |
Biomarker
|
disease |
BEFREE |
Recently, genetic markers within a locus on 7q21.11 containing the SEMA3A, SEMA3C, and SEMA3D genes were reported to be associated with Hirschsprung disease (HSCR).
|
27469503 |
2016 |
|
Truncus Arteriosus, Persistent
|
0.300 |
Biomarker
|
disease |
CTD_human |
ENU induced mutations causing congenital cardiovascular anomalies.
|
15548583 |
2004 |
|
Abdominal Pain
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Constipation
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Diarrhea
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Dwarfism
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Sensorineural Hearing Loss (disorder)
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Intestinal Obstruction
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Nausea and vomiting
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These data suggest that SEMA3C expression is differentially regulated in the development and progression of breast versus oral neoplasia, and that increased expression of SEMA3C may be modulating breast cancer progression and angiogenesis, and could represent a biomarker of metastatic disease.
|
25910410 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Full-Length Semaphorin-3C Is an Inhibitor of Tumor Lymphangiogenesis and Metastasis.
|
25808871 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunostaining of primary tumor indicated the rate of Ki-67 positive carcinoma cells was decreased, whereas that of apoptotic cells was significantly increased in sema3C-silenced tumor.
|
22924992 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
SEMA3C depletion inhibited tumor growth <i>in vitro</i>.
|
31649890 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Sema3C protein, a member of the class 3 family of secreted semaphorins, play an important role in tumor development by regulating cell proliferation, migration, invasion, and angiogenesis processes.
|
31726800 |
2019 |
|
Thyroid Neoplasm
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|