DEAF1, DEAF1 transcription factor, 10522

N. diseases: 156; N. variants: 13
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.310 GeneticVariation disease BEFREE In a controlled, univariate model, an interaction between the [C]-allele and physical activity indicated that only among athletes, the variant resulting in an imperfect NUDR binding site was associated with a lower depression score. 26866771 2015
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.310 Biomarker disease PSYGENET Chronic social defeat downregulates the 5-HT1A receptor but not Freud-1 or NUDR in the rat prefrontal cortex. 20026183 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.310 Biomarker disease PSYGENET These results point to the importance of understanding the mechanism for the differential regulation of Freud-1 and NUDR in the PFC as a basis for understanding the related effects of chronic stress on the serotonin system (serotonin-related transcription factors) and stress-related disorders like depression. 19647046 2009
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.310 Biomarker disease PSYGENET Cell-specific repressor or enhancer activities of Deaf-1 at a serotonin 1A receptor gene polymorphism. 16467535 2006
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.310 Biomarker disease PSYGENET 5-HT1A receptors, gene repression, and depression: guilt by association. 15534042 2004