|
Adolescent idiopathic scoliosis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
|
30019117 |
2018 |
|
SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
|
30019117 |
2018 |
|
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
21833088 |
2011 |
|
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
21833088 |
2011 |
|
Hepatitis B
|
0.020 |
Biomarker
|
disease |
BEFREE |
This study explored BATF as a regulator of Th17 differentiation in normal and hepatitis B virus (HBV) transgenic mice.
|
30498928 |
2019 |
|
HIV Infections
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Recently, the study of human immunodeficiency virus (HIV) infection demonstrated that PD-1 could induce the expression of basic leucine zipper ATF-like transcription factor (BATF) to inhibit CD8<sup>+</sup> T cell function.
|
31681314 |
2019 |
|
Colitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Importantly, RORγt-independent manifestation of intestinal GvHD was completely dependent on BATF-regulated GM-CSF<sup>+</sup> T cells as BATF/RORγt double-deficient T cells failed to induce colitis and the antibody-mediated blockage of IL-7/IL-7R interaction and GM-CSF significantly diminished signs of intestinal GvHD elicited by RORγt-deficient donor T cells.
|
29910804 |
2018 |
|
Hepatitis B
|
0.020 |
Biomarker
|
disease |
BEFREE |
T helper (Th) 17 cells have a critical role in the pathogenesis of chronic hepatitis B virus (HBV) infection, and basic leucine zipper transcription factor, ATF-like (BATF) is a newly identified transcriptional factor regulating the differentiation of Th17 cells.
|
29164410 |
2018 |
|
Colitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Colitis-associated Batf(-/-) tumours lacked IL-17a(+)IL-23R(+)IL-6(+)CD4(+) T cells, hence displaying characteristics reminiscent of human CRC-infiltrating CD4(+) T cells.
|
25838550 |
2016 |
|
HIV Infections
|
0.020 |
Biomarker
|
group |
BEFREE |
We also highlight the ensemble of transcriptional factors such as BATF, BLIMP-1/PRDM1, FoxP3, DTX1 and molecular pathways that facilitate the recruitment and differentiation of suppressor T cells in response to HIV infection.
|
23514593 |
2013 |
|
Meningitis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We describe the expression and regulation of the gene sfaX(II) located near the Sfa(II) fimbrial determinant in the newborn meningitis Escherichia coli (NMEC) isolate IHE3034. sfaX(II) belongs to a gene family, the 17-kDa genes, typically located downstream (300-3000bp) of different fimbrial operons found in E. coli isolates of uropathogenic and newborn meningitis origin.
|
19103276 |
2009 |
|
Meningitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
In this report we have investigated the role of the sfaX(II) gene associated to the Sfa(II) fimbrial determinant in the E. coli isolate IHE3034. sfaX(II) belongs to a subfamily of genes, the 17k Da genes, located near different fimbrial operons in uropathogenic and newborn meningitis E. coli (NMEC) strains.
|
19486641 |
2009 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Lentivirus-mediated short hairpin RNA (shRNA) was used to knockdown BATF expression in the human A549 NSCLC cell line and assessed by RT-qPCR and Western blot.
|
31777604 |
2019 |
|
Tuberculosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
There was a positive correlation between BATF expression and PD-1 expression in ATB patients (for CD4<sup>+</sup> T cells, <i>r</i> = 0.6761, <i>P</i> = 0.0158; for CD8<sup>+</sup> T cells, <i>r</i> = 0.6104, <i>P</i> = 0.0350).
|
31681314 |
2019 |
|
Active tuberculosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
There was a positive correlation between BATF expression and PD-1 expression in ATB patients (for CD4<sup>+</sup> T cells, <i>r</i> = 0.6761, <i>P</i> = 0.0158; for CD8<sup>+</sup> T cells, <i>r</i> = 0.6104, <i>P</i> = 0.0350).
|
31681314 |
2019 |
|
Latent Tuberculosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Results:</b> The percentages of BATF<sup>+</sup>CD4<sup>+</sup> (<i>P</i> = 0.0003 and <i>P</i> < 0.0001, respectively) and BATF<sup>+</sup>CD8<sup>+</sup> (<i>P</i> = 0.0003 and <i>P</i> = 0.0003, respectively) cells were significantly increased in ATB patients compared with LTBI and HC.
|
31681314 |
2019 |
|
Arthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
BATF was upregulated in the synovial tissues of joints in which inflammatory arthritis had been caused by CIA or K/BxN serum transfer.
|
30071881 |
2018 |
|
Graft-vs-Host Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, this study identifies BATF-dependent pathogenic GM-CSF+ effector T cells as critical promoters of intestinal inflammation in GVHD and hence putatively provides mechanistic insight into inflammatory processes previously assumed to be selectively Th17 driven.
|
29376889 |
2018 |
|
Complete atrioventricular block
|
0.010 |
Biomarker
|
disease |
BEFREE |
Intrahepatic BATF-positive infiltrating cells were enriched in portal area of CHB patients, and more positive cells were found in patients with higher inflammation grade.
|
29164410 |
2018 |
|
Ki-1+ Anaplastic Large Cell Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, the AP-1-BATF module establishes TH17/group 3 innate lymphoid cells (ILC3)-associated gene expression in ALCL cells, including marker genes such as AHR, IL17F, IL22, IL26, IL23R and RORγt.
|
29588546 |
2018 |
|
Neurodegenerative Disorders
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Showing that B cells are major source of IL-10 and IL-35 in-vivo and identifying transcription factors that contribute to IL-10 and IL-35 expression in the activated B-cell, suggest that the BATF/IRF-4/IRF-8 axis can be exploited therapeutically to regulate physiological levels of IL-10/IL-35-Bregs and that adoptive transfer of autologous Bregs might be an effective therapy for autoimmune and neurodegenerative diseases.
|
30117603 |
2018 |
|
Hepatitis B, Chronic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Increased BATF expression is associated with the severity of liver damage in patients with chronic hepatitis B.
|
29164410 |
2018 |
|
Intestinal Graft Versus Host Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Together, this study provides a crucial example of a BATF-dependent, however, IL-23R signaling- and RORγt-, i.e., Th17 fate-independent regulation of a colitogenic T cell population critically impacting the current understanding of intestinal GvHD.
|
29910804 |
2018 |
|
Degenerative polyarthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Pharmacological inhibition of BATF/JUN transcriptional activity reduced the expression of matrix-degrading enzymes and protected against experimental OA in mice.
|
27147707 |
2017 |
|
Autoimmune Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Because B cell-activating transcription factor (BATF) controls Th17 and autoimmunity, we proposed that BATF may play a critical role in OAD.
|
26844425 |
2016 |