Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0040425
Disease: Tonsillitis
Tonsillitis
0.010 AlteredExpression disease BEFREE <i>In vitro</i>, repeated TLR9 stimulation induced APRIL expression in tonsillar B cells from control patients with tonsillitis. 27920152 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE Tumor growth-promoting as well as apoptosis-inducing effects of APRIL have been described. 11550092 2001
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 PosttranslationalModification group BEFREE APRIL and BAFF are involved in a variety of tumor and autoimmune diseases, including B-cell malignancies. 15070697 2004
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.060 PosttranslationalModification group BEFREE APRIL and BAFF are involved in a variety of tumor and autoimmune diseases, including B-cell malignancies. 15070697 2004
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.060 Biomarker group BEFREE APRIL may serve as a down modulator of serological and/or clinical autoimmunity in patients with SLE. 15308519 2004
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.070 Biomarker disease BEFREE APRIL stimulated RA FLS, but not OA FLS, to produce IL-6, TNFalpha, IL-1beta, and APRIL itself. 17968879 2007
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.050 AlteredExpression group BEFREE APRIL is overexpressed in cancer: link with tumor progression. 19291294 2009
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.010 Biomarker phenotype BEFREE APRIL knockdown suppresses migration and invasion of human colon carcinoma cells. 19573525 2009
CUI: C0398650
Disease: Immune thrombocytopenic purpura
Immune thrombocytopenic purpura
0.010 AlteredExpression disease BEFREE APRIL is over expressed in untreated active ITP patients and might be a pathogenic factor of this disorder. 19824872 2009
CUI: C1319315
Disease: Adenocarcinoma of large intestine
Adenocarcinoma of large intestine
0.010 Biomarker disease BEFREE APRIL is a novel clinical chemo-resistance biomarker in colorectal adenocarcinoma identified by gene expression profiling. 20003335 2009
CUI: C4054543
Disease: Membranous Lupus Nephritis
Membranous Lupus Nephritis
0.010 AlteredExpression disease BEFREE APRIL was prominently expressed in glomeruli with proliferative, but not membranous, lupus nephritis. 20890272 2011
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.060 Biomarker group BEFREE APRIL has also been associated with a wide range of solid malignancies, including colorectal cancer (CRC). 22705846 2012
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis
0.020 Biomarker disease BEFREE APRIL could be a potential biomarker for predicting difficult-to-treat cases of lupus nephritis. 23171638 2012
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.030 Biomarker phenotype BEFREE APRIL induces tumorigenesis and metastasis of colorectal cancer cells via activation of the PI3K/Akt pathway. 23383143 2013
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.040 Biomarker phenotype BEFREE APRIL induces tumorigenesis and metastasis of colorectal cancer cells via activation of the PI3K/Akt pathway. 23383143 2013
CUI: C0023418
Disease: leukemia
leukemia
0.010 Biomarker disease BEFREE APRIL-TCL1 double-Tg mice showed a significantly earlier onset of leukemia and disruption of splenic architecture, and survival was significantly reduced. 24100449 2013
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia
0.010 Biomarker disease BEFREE APRIL-TCL1 double-Tg mice showed a significantly earlier onset of leukemia and disruption of splenic architecture, and survival was significantly reduced. 24100449 2013
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE APRIL can stimulate tumor cell growth and is up-expressed in cancer tissues, especially in CRC (colorectal cancer). 24771268 2014
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.060 AlteredExpression group BEFREE APRIL can stimulate tumor cell growth and is up-expressed in cancer tissues, especially in CRC (colorectal cancer). 24771268 2014
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.050 AlteredExpression group BEFREE APRIL can stimulate tumor cell growth and is up-expressed in cancer tissues, especially in CRC (colorectal cancer). 24771268 2014
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.020 AlteredExpression disease BEFREE APRIL can stimulate tumor cell growth and is up-expressed in cancer tissues, especially in CRC (colorectal cancer). 24771268 2014
Malignant neoplasm of colon and/or rectum
0.010 AlteredExpression disease BEFREE APRIL can stimulate tumor cell growth and is up-expressed in cancer tissues, especially in CRC (colorectal cancer). 24771268 2014
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.010 AlteredExpression disease BEFREE APRIL mRNA levels were significantly increased in GC tissues compared with adjacent tissues and high expression levels of APRIL in tumor cells significantly correlated with poor overall survival in patients receiving cisplatin adjuvant treatment. 25612651 2015
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.010 AlteredExpression disease BEFREE APRIL mRNA levels were significantly increased in GC tissues compared with adjacent tissues and high expression levels of APRIL in tumor cells significantly correlated with poor overall survival in patients receiving cisplatin adjuvant treatment. 25612651 2015
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.040 Biomarker phenotype BEFREE APRIL promotes breast tumor growth and metastasis and is associated with aggressive basal breast cancer. 25750171 2015