|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, these results suggest that Prx4 may be a target for preventing AβO toxicity in AD.Graphical abstract .
|
31147869 |
2019 |
|
Bacterial Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Dietary GRA induced a down-regulation of hepatic stress-responsive heat shock proteins (grp-78, grp-170, grp-94, grp-75), while bacterial infection caused a down-regulation in antioxidant genes (prdx4 and mn-sod).
|
31695116 |
2019 |
|
Carcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
A meta-analysis established an increase in L-plastin and PRDX4 mRNA expression in numerous human cancers, including breast and prostate carcinomas.
|
30583289 |
2019 |
|
Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Elevated ER stress exacerbates dextran sulfate sodium-induced colitis in PRDX4-knockout mice.
|
30578917 |
2019 |
|
Obesity
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The aim of the study was to investigate peroxiredoxin 4 levels in women with polycystic ovarian syndrome (PCOS) and/or obesity.
|
30980996 |
2019 |
|
Pneumonia
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, we found that upregulation of Cd5l and reduction of Hspa1 and peroxiredoxin-4 was associated with PM<sub>2.5</sub>-induced pulmonary inflammation and oxidative stress.
|
31279222 |
2019 |
|
Secondary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Subsequent in vivo studies confirmed that PRDX4 deficiency blocks HCC tumor growth and pulmonary metastasis.
|
31256347 |
2019 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
Biomarker
|
disease |
BEFREE |
We screened eight highly expressed proteins related to lymph node metastasis in OSCC and found that the expression levels of SOD2, BST2, CAD, ITGB6, and PRDX4 were significantly elevated in patients with lymph node metastasis compared to the patients without lymph node metastasis.
|
30779878 |
2019 |
|
Hepatocarcinogenesis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, for hepatocarcinogenesis, wild-type (WT), PRDX4 knockout (PRDX4<sup>-/y</sup>), and human PRDX4 transgenic (hPRDX4<sup>+/+</sup>) mice were given a weekly intraperitoneal injection of diethylnitrosamine for 25 weeks.
|
29687726 |
2019 |
|
Nonalcoholic Steatohepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Previously, we reported that PRDX4 can restrain the initiation and progression of nonalcoholic steatohepatitis by reducing local and systemic reactive oxygen species (ROS) levels.
|
29687726 |
2019 |
|
Pneumonitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, we found that upregulation of Cd5l and reduction of Hspa1 and peroxiredoxin-4 was associated with PM<sub>2.5</sub>-induced pulmonary inflammation and oxidative stress.
|
31279222 |
2019 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Peroxiredoxin 4 (PRDX4): Its critical in vivo roles in animal models of metabolic syndrome ranging from atherosclerosis to nonalcoholic fatty liver disease.
|
29341349 |
2018 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Peroxiredoxin 4 (PRDX4): Its critical in vivo roles in animal models of metabolic syndrome ranging from atherosclerosis to nonalcoholic fatty liver disease.
|
29341349 |
2018 |
|
Cholestasis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, the composition of the hepatic bile acids (BAs) was more beneficial for Tg BDL mice than for WT BDL mice, suggesting that PRDX4 overexpression may affect BA metabolism during cholestasis.
|
30149550 |
2018 |
|
Liver Failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
Double Knockout of Peroxiredoxin 4 (Prdx4) and Superoxide Dismutase 1 (Sod1) in Mice Results in Severe Liver Failure.
|
30050648 |
2018 |
|
Non-alcoholic Fatty Liver Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
We generated unique human PRDX4 (hPRDX4) transgenic (Tg) mice on a C57BL/6J background and investigated the critical and diverse protective roles of PRDX4 against diabetes mellitus, atherosclerosis, insulin resistance, and nonalcoholic fatty liver disease (NAFLD) as well as evaluated its role in the intestinal function in various animal models.
|
29341349 |
2018 |
|
Metabolic Syndrome X
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our published data have shown that PRDX4 helps prevent the progression of metabolic syndrome by reducing local and systemic oxidative stress and synergistically suppressing steatosis, inflammatory reactions, and/or apoptotic activity.
|
29341349 |
2018 |
|
Middle Cerebral Artery Occlusion
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, genome-wide RNA sequencing (RNA-seq) analysis revealed that peroxiredoxin4 (PRDX4) was highly expressed in MSCs, which mainly contributed to their antioxidant impacts on MCAO rats and oxygen-glucose deprivation (OGD)-treated endothelium.
|
30613272 |
2018 |
|
Steatohepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our published data have shown that PRDX4 helps prevent the progression of metabolic syndrome by reducing local and systemic oxidative stress and synergistically suppressing steatosis, inflammatory reactions, and/or apoptotic activity.
|
29341349 |
2018 |
|
Fatty Liver Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Interestingly, seven of these proteins, including keratin cytoskeletal 8 and 18, peroxiredoxin-4, and protein disulfide isomerase, are known to undergo GlcNAcylation modification, most of which are related to structural and stress-related proteins in NASH model animals.
|
30042374 |
2018 |
|
Hyperalgesia
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
After administration of recombinant PTD-Cu/Zn SOD to these tumor-burden rats, their hyperalgesia was significantly attenuated and peroxiredoxin 4 expression was significantly increased.
|
28391978 |
2017 |
|
Multiple Myeloma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MM.1R and MM.1S cell lines were treated with 15d-PGJ<sub>2</sub> at 1-10μM and evaluated with regard to proliferation, mRNA expression of PRDX1, PRDX4, GRP78, GRP94, CHOP, BCL-2 and BAX.
|
28506771 |
2017 |
|
Degenerative polyarthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results indicate that PRDX4 might play a protective role in OA cartilage degeneration.
|
28391163 |
2017 |
|
Atrophy of testis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In our previous study, PRDX4 knockout mice displayed testicular atrophy with an increase in cell death due to oxidative stress.
|
28584396 |
2017 |
|
NONAKA MYOPATHY
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our study indicates that downregulation of PrdxIV affects ER redox state that may contribute to misfolding and aggregation of proteins in GNE myopathy.
|
28895049 |
2017 |