CENPC, centromere protein C, 1060

N. diseases: 16; N. variants: 2
Disease: Progressive cGVHD ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3539781
Disease: Progressive cGVHD
Progressive cGVHD 		0.010 GeneticVariation disease BEFREE These constructs antagonize the cognate TCR and bind with high affinity to their cell-bound CD74 receptor on macrophages and dendritic cells, thereby competitively inhibiting downstream signaling and pro-inflammatory effects of macrophage migration inhibitory factor (MIF) and its homolog, D-dopachrome tautomerase (D-DT=MIF-2) that bind to identical residues of CD74 leading to progressive disease. 30683115 2019