Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.060 AlteredExpression group BEFREE Known inhibitors of KDM5B were also able to induce HEXIM1 expression, inhibit cell proliferation, induce differentiation, potentiate sensitivity to cancer chemotherapy, and inhibit breast tumor metastasis. 31805991 2019
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.060 Biomarker group BEFREE Incorporating well-characterized pharmacodynamic markers, such as HEXIM1 and other genes described here, can provide a better understanding of potential efficacy and toxicity associated with inhibiting BET family proteins and informs early clinical decisions on BET inhibitor development programs.Mol Cancer Ther; 16(2); 388-96.©2016 AACR. 27903752 2017
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.060 AlteredExpression group BEFREE Decreased Hexim-1 expression in animal models of chronic diseases such as left ventricular hypertrophy, obesity and cancer triggered significant changes in adaptation and remodeling. 28013147 2017
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.060 AlteredExpression group BEFREE Utility of HEXIM1 mRNA may be limited to higher concentrations.<i>Clin Cancer Res; 23(4); 1025-35.©2017 AACR</i>. 28073847 2017
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.060 Biomarker group BEFREE HEXIM1 plays an important role in inhibiting cancer cell-specific gene transcription while also facilitating anti-cancer gene expression. 27058786 2016
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.060 AlteredExpression group BEFREE HEXIM1 and the control of transcription elongation: from cancer and inflammation to AIDS and cardiac hypertrophy. 17671421 2007