Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002871
Disease: Anemia
Anemia
0.100 Biomarker disease BEFREE Repercussion of myeloid cell phenotype specific to BM after burn injury could plausibly account for a defective late stage RBC maturation resulting in anemia of critical illness. 31824951 2019
CUI: C0002871
Disease: Anemia
Anemia
0.100 GeneticVariation disease BEFREE BACKGROUNDAlthough it is considered that the pathogenesis of diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM) is primarily due to chronic hyperglycemia resulting in vascular changes and retinal ischemia, the red blood cells (RBCs) disorders might also represent an important pathophysiological risk factor.OBJECTIVETo evaluate whether the RBC properties contribute to DR development and progression in T2DM.METHODSThis prospective observational study comprised 247 persons with T2DM free of DR or with non proliferative DR without any signs of anaemia. 30103306 2019
CUI: C0002871
Disease: Anemia
Anemia
0.100 Biomarker disease BEFREE To evaluate the effectiveness of anemia management and audit with feedback practices in reducing overuse of RBC transfusion. 30357323 2019
CUI: C0002871
Disease: Anemia
Anemia
0.100 Biomarker disease BEFREE Twenty percent of cases showed evidence of acute coronary ischemia that was first detected during transfusion with rising troponins or electrocardiographic abnormalities, all in association with RBC transfusion for anemia. 30488953 2019
CUI: C0002871
Disease: Anemia
Anemia
0.100 Biomarker disease BEFREE ESAs (including biosimilars) may be offered to patients with chemotherapy-associated anemia whose cancer treatment is not curative in intent and whose hemoglobin has declined to < 10 g/dL.RBC transfusion is also an option. 30971397 2019
CUI: C0002871
Disease: Anemia
Anemia
0.100 Biomarker disease BEFREE ESAs (including biosimilars) may be offered to patients with chemotherapy-associated anemia whose cancer treatment is not curative in intent and whose hemoglobin has declined to < 10 g/dL.RBC transfusion is also an option. 30969847 2019
CUI: C0002871
Disease: Anemia
Anemia
0.100 Biomarker disease BEFREE For the PS negative sub-fraction of RBCs, the size of the RBC was as expected but the average hemoglobin, Hb, content was below the threshold which defines anemia. 30617361 2019
CUI: C0002871
Disease: Anemia
Anemia
0.100 Biomarker disease BEFREE Using a structured literature review and grading process, the Transfusion and Anemia Expertise Initiative panel concluded that there is currently insufficient evidence to recommend specific RBC transfusion variables in children requiring extracorporeal membrane oxygenation, ventricular assist device, or renal replacement therapy support. 30161071 2018
CUI: C0002871
Disease: Anemia
Anemia
0.100 Biomarker disease BEFREE The Transfusion and Anemia Expertise Initiative Consensus Conference developed pediatric specific recommendations regarding RBC transfusion management in the critically ill child with acute bleeding, as well as recommendations to help guide future research priorities. 30161067 2018
CUI: C0002871
Disease: Anemia
Anemia
0.100 GeneticVariation disease BEFREE Fifty-eight infants (15 after pediatric surgery and 43 after cardiac surgery) with anemia requiring RBC transfusion were included. 29406374 2018
CUI: C0002871
Disease: Anemia
Anemia
0.100 Biomarker disease BEFREE Transfusion and Anemia Expertise Initiative developed pediatric-specific good practice statements and recommendations regarding RBC transfusion management in the general PICU population, as well as recommendations to guide future research priorities. 30161064 2018
CUI: C0002871
Disease: Anemia
Anemia
0.100 Biomarker disease BEFREE Pathologists' most relevant recommendation: "Do not transfuse more units of blood than absolutely necessary"; highest priority: "Do not transfuse more than the minimum number of RBC units necessary to relieve symptoms of anemia or to return a patient to a safe hemoglobin range (7-8 g/dL in stable, noncardiac inpatients)." 29425260 2018
CUI: C0002871
Disease: Anemia
Anemia
0.100 Biomarker disease BEFREE The Transfusion and Anemia Expertise Initiative Consensus Conference developed specific recommendations regarding RBC transfusion management in critically ill children with respiratory failure, as well as recommendations to guide future research. 30161065 2018
CUI: C0002871
Disease: Anemia
Anemia
0.100 GeneticVariation disease BEFREE Low-dose thalidomide and prednisone alone or combined are effective therapies in some persons with primary myelofibrosis (PMF) and anemia with or with RBC transfusion dependence. 29335406 2018
CUI: C0002871
Disease: Anemia
Anemia
0.100 Biomarker disease BEFREE Transfusion and Anemia Expertise Initiative Consensus Conference experts developed and voted on a total of four clinical and four research recommendations focused on RBC transfusion in the critically ill child with nonhemorrhagic shock. 30161066 2018
CUI: C0002871
Disease: Anemia
Anemia
0.100 Biomarker disease BEFREE The Transfusion and Anemia Expertise Initiative recommendations on RBC transfusions are based on clinical evidence and aim to limit unnecessary and potentially harmful transfusions. 30161073 2018
CUI: C0002871
Disease: Anemia
Anemia
0.100 Biomarker disease BEFREE RBC clearance through loss of complement regulatory proteins (CRPs) is a significant contributor to anemia in Plasmodium falciparum infection, but its role in Plasmodium vivax infection is unknown. 30429373 2018
CUI: C0002871
Disease: Anemia
Anemia
0.100 AlteredExpression disease BEFREE RBC-EV levels correlated with patient hematocrit, reflecting degree of anemia. 30214417 2018
CUI: C0002871
Disease: Anemia
Anemia
0.100 Biomarker disease BEFREE In patients with sickle cell disease, Transfusion and Anemia Expertise Initiative recommends: 1) RBC transfusion to achieve a target hemoglobin concentration of 10 g/dL rather than hemoglobin of less than 30% prior to surgical procedures requiring general anesthesia and 2) exchange transfusion over simple (nonexchange) transfusion if the child's condition is deteriorating (based on clinical judgment), otherwise a simple, nonexchange RBC transfusion is recommended. 30161070 2018
CUI: C0002871
Disease: Anemia
Anemia
0.100 Biomarker disease BEFREE Transfusion and Anemia Expertise Initiative Consensus Conference experts developed and agreed upon two clinical and two research recommendations focused on RBC transfusion in the critically ill child with acute brain injury. 30161068 2018
CUI: C0002871
Disease: Anemia
Anemia
0.100 Biomarker disease BEFREE The Transfusion and Anemia Expertise Initiative recommendations provide important clinical guidance and applicable tools to avoid unnecessary RBC transfusions. 30180125 2018
CUI: C0002871
Disease: Anemia
Anemia
0.100 Biomarker disease BEFREE The Transfusion and Anemia Expertise Initiative consensus conference developed recommendations for selection and processing of RBC units for critically ill children. 30161072 2018
CUI: C0002871
Disease: Anemia
Anemia
0.100 Biomarker disease BEFREE Transfusion decision making (TDM) in the critically ill requires consideration of: (1) anemia tolerance, which is linked to active pathology and to physiologic reserve, (2) differences in donor RBC physiology from that of native RBCs, and (3) relative risk from anemia-attributable oxygen delivery failure vs hazards of transfusion, itself.Current approaches to TDM (e.g. hemoglobin thresholds) do not: (1) differentiate between patients with similar anemia, but dissimilar pathology/physiology, and (2) guide transfusion timing and amount to efficacy-based goals (other than resolution of hemoglobin thresholds). 28941545 2017
CUI: C0002871
Disease: Anemia
Anemia
0.100 GeneticVariation disease BEFREE The frequency of RBC transfusion among patients with severe (hematocrit, < 21%), moderate (hematocrit, 21-30%), and mild (hematocrit, > 30%) anemia in restrictive transfusion protocol ICUs was 67%, 19%, and 4%, respectively, compared with 60%, 14%, and 2% for those in ICUs without an restrictive transfusion protocol. 27632673 2017
CUI: C0002871
Disease: Anemia
Anemia
0.100 Biomarker disease BEFREE However, autoreactive SwHEL mice had induction of tolerance in both B-2 and B-1 B cells with anti-RBC autoantibody production without anemia. 29163471 2017