Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell
0.100 Biomarker disease BEFREE Modulation of the AC/cAMP/PKA pathway could have the potential to be an effective therapeutic approach for SCD through shear-induced improvements of RBC deformability. 31306111 2019
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell
0.100 Biomarker disease BEFREE In this study, we explored five patients with SCD and multiple RBC alloantibodies who received various forms of immunosuppressive therapy in an attempt to prevent or treat severe DHTRs. 30848512 2019
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell
0.100 Biomarker disease BEFREE Forty percent of institutions (33% of non-SCTCs) employ RBC genotyping to evaluate the red cell phenotype for SCD patients. 30740798 2019
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell
0.100 Biomarker disease BEFREE The contribution of intracellular hemoglobin (Hb) oxidation to RBC-derived microparticle (MP) formation is poorly defined in sickle cell disease (SCD). 30385713 2018
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell
0.100 Biomarker disease BEFREE Loss of RBC deformability, sickling and irreversible membrane damage causes abnormal blood rheology, and increases viscosity which contributes to vasoocclusion and other SCD pathophysiology. 29660913 2018
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell
0.100 GeneticVariation disease BEFREE In sickle cell disease (SCD), 'disease severity' associates with increased RBC adhesion to quiescent endothelium, but the impact on activated endothelium is not known. 29905377 2018
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell
0.100 GeneticVariation disease BEFREE Transfusion and Anemia Expertise Initiative developed specific pediatric recommendations regarding RBC transfusion management in critically ill children with sickle cell disease, oncologic disease, and hematopoietic stem cell transplant and recommendations to help guide future research priorities. 30161070 2018
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell
0.100 GeneticVariation disease BEFREE Significant heterogeneity in RBC adherence response to hypoxia was seen among SCD patients. 28387057 2017
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell
0.100 Biomarker disease BEFREE Conclusion Our study suggests that RBC Duffy expression increases levels of WBCs in SCD patients and that Duffy genotype may not be a potential biomarker for end-organ damage in SCD. 26917322 2016
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell
0.100 Biomarker disease BEFREE These actions are relevant to understanding how aromatic aldehydes may affect RBC membrane permeability per se as well as HbS polymerisation and thereby inform design of compounds most efficacious in ameliorating the complications of SCD. 24594314 2015
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell
0.100 Biomarker disease BEFREE There is no universal standard of care for the appropriate selection of RBC products for patients with SCD. 21277259 2011
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell
0.100 Biomarker disease BEFREE We postulate that ADRB2 and ADCY6 polymorphisms may influence SCD severity through the mechanism of RBC adhesion. 18324973 2008
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell
0.100 Biomarker disease BEFREE The Lu/BCAM adhesion glycoproteins were first identified as laminin-10/11 erythroid receptors involved in RBC adhesion to endothelium in sickle cell anemia. 18948049 2008
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell
0.100 GeneticVariation disease BEFREE To make these latter points we focus on what is known concerning changes in the RBC proteome in Sickle Cell Disease. 18040063 2007
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell
0.100 Biomarker disease BEFREE Red blood cells from patients with sickle cell disease (SS RBC) adhere to laminin and over-express the high-affinity laminin receptor basal cell adhesion molecule/Lutheran protein (B-CAM/LU). 14755370 2004
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell
0.100 Biomarker disease BEFREE The usefulness of DNA genotyping for RBC antigens as a tool for the management of multiply-transfused patients with sickle cell disease (SCD) to overcome the limitations of hemagglutination assays was evaluated. 11896340 2002
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell
0.100 Biomarker disease BEFREE We propose that the more deformable the sickle RBC are, the greater their adherence to vascular endothelium, and the more they cause vaso-occlusive crises, RBC deformability and the percentage of dense cells (or ISC) seem to have a predictive value of the frequency and severity of painful crises in sickle cell anemia. 3167204 1988
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell
0.100 AlteredExpression disease BEFREE Patients with sickle cell disease and alpha thalassemia had higher hemoglobin (Hb) levels, RBC counts, and Hb A2 levels, and lower reticulocyte counts, MCV, MCH, and Hb F levels than those with a normal alpha genotype. 2827816 1988