The induction of diabetes decreased RBC, MCHC, PCV, MCV and WBC (P < 0.05), but the oral supplement of SPM (30 mg/kg body weight) could improve RBC, WBC, MCHC, PCV and MCV in rats (P < 0.05).
Baseline Na-Li CT activity was significantly higher for people who developed diabetes at follow-up (n = 101) than for those who remained non-diabetic (364 +/- 184 vs 300 +/- 150 micromol/l RBC/h, P < 0.001).
Our study is the first to present evidence that markers of lipoprotein metabolism (Lp[a]), oxidative stress (plasma and RBC-MDA), and cellular fragility (hemolysis) are abnormal in nondiabetic relatives of type 1 diabetic subjects, thereby supporting the view that familial elements of diabetes even precede the onset of diabetes.