Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0948201
Disease: Alloimmunisation
Alloimmunisation
0.080 GeneticVariation disease BEFREE The objective of this study was to evaluate the risk of RBC alloimmunization in MM patients treated with DARA. 31729042 2020
CUI: C0948201
Disease: Alloimmunisation
Alloimmunisation
0.080 GeneticVariation disease BEFREE Alloimmunization is a known risk of transfusion therapy caused by exposure to foreign RBC antigens. 30548476 2019
CUI: C0948201
Disease: Alloimmunisation
Alloimmunisation
0.080 GeneticVariation disease BEFREE In this study we aimed to determine the prevalence, alloimmunization risk factors, antigenic exposure, and evaluation of antigen- (C, c, E, e, Mi<sup>a</sup> ) matched RBC transfusion. 30443908 2019
CUI: C0948201
Disease: Alloimmunisation
Alloimmunisation
0.080 Biomarker disease BEFREE RBC alloimmunization represents a significant immunological challenge for patients requiring lifelong transfusion support. 30429364 2018
CUI: C0948201
Disease: Alloimmunisation
Alloimmunisation
0.080 Biomarker disease BEFREE However, although distinct alloantigens reside on the RBC surface at different levels, most alloantigens also represent completely different structures, making it difficult to separate the potential impact of differences in Ag density from other alloantigen features that may also influence RBC alloimmunization. 28250159 2017
CUI: C0948201
Disease: Alloimmunisation
Alloimmunisation
0.080 Biomarker disease BEFREE The impact of vaccination on RBC alloimmunization in a murine model. 28597520 2017
CUI: C0948201
Disease: Alloimmunisation
Alloimmunisation
0.080 Biomarker disease BEFREE These findings raise the possibility that patients with IFN-α/β-mediated conditions, including autoimmunity and viral infections, may have an increased risk of RBC alloimmunization and may benefit from personalized transfusion protocols and/or targeted therapies. 28630094 2017
CUI: C0948201
Disease: Alloimmunisation
Alloimmunisation
0.080 GeneticVariation disease BEFREE Because of the high risk of alloimmunization of these patients and the labor-intensive nature of adsorption techniques, we decided to evaluate the feasibility of selecting antigen-matched units on the basis of RBC genotyping. 24120494 2014